老年冠心病合并心力衰竭患者发生衰弱的危险因素分析及其对预后的影响

Analysis of risk factors for frailty in older patients with coronary heart disease and heart failure and its effects on prognosis

中文关键词: 老年    冠心病    心力衰竭    衰弱    猝死,心脏    影响因素

英文关键词: older adultscoronary diseaseheart failurefrailtydeathsuddencardiacinfluencing factor

中文摘要:

      目的 分析老年冠心病(CHD)合并心力衰竭(HF)患者发生衰弱的相关因素，并探讨衰弱对其再住院、心源性猝死的影响。方法 回顾性分析216例老年CHD合并HF患者的临床资料，统计衰弱发生情况，分析衰弱发生的影响因素及其与再住院、心源性猝死的关系。结果 衰弱发生率为48.61%(105/216)。年龄、查尔森共病指数、左室射血分数(LVEF)、血红蛋白、白蛋白、脑利尿钠肽(BNP)是老年CHD合并HF患者发生衰弱的独立影响因素(P <0.05)。不同衰弱状态患者再住院和心源性猝死差异均有统计学意义(P <0.05)。衰弱前期和衰弱是老年CHD合并HF患者再住院事件、心源性猝死事件的独立危险因素(P <0.05)。结论 年龄、查尔森共病指数、LVEF、血红蛋白、白蛋白、BNP可能是老年CHD合并HF患者发生衰弱的独立影响因素，且衰弱状态与其再住院事件和心源性猝死事件相关。

英文摘要:

      Objective To analyze the factors associated with frailty in older patients with coronary heart disease(CHD)complicated with heart failure(HF),and investigate the effects of frailty on rehospitalization and sudden cardiac death.Methods Clinical data of 216 older patients with CHD and HF were retrospectively analyzed.The incidence of frailty was documented,and the influencing factors of frailty as well as its association with rehospitalization and sudden cardiac death were examined.Results The incidence of frailty was 48.61%(105/216).Age,Charlson comorbidity index,left ventricular ejection fraction(LVEF),hemoglobin,albumin,and brain natriuretic peptide(BNP)were identified as possible independent influencing factors for the occurrence of frailty in older patients with CHD and HF(P＜0.05).Statistically significant differences were observed in rehospitalization and sudden cardiac death among patients with different frailty statuses(P＜0.05).Frailty status was a possible independent risk factor for rehospitalization and sudden cardiac death events in older patients with CHD and HF(P＜0.05).Conclusion Age,Charlson comorbidity index,LVEF,hemoglobin,albumin,and BNP are possible independent influencing factors for frailty in older patients with CHD and HF,and frailty status may be associated with rehospitalization and sudden cardiac death events in these patients.