老年人原发性胆汁性胆管炎临床特征分析

Clinical characteristics of primary billiary cholangistis in elderly patients

中文关键词: 原发性胆汁性胆管炎  老年人  临床特征

英文关键词: Primary billiary cholangistis  Elderly  Clinical characteristics

中文摘要:

      目的 探讨老年人原发性胆汁性胆管炎的临床特征.方法 原发性胆汁性胆管炎患者,共121例,分为老年组及非老年组,老年组44例,非老年组77例;收集并比较两组PBC患者的临床资料、检验及影像检查资料.结果 老年组中临床症状发生率最高的是乏力、黄疸,非老年组中为乏力、纳差,组间比较临床症状发生率差异不显著;老年组的TBIL、DBIL、ALT、AST、ALP、GGT平均值均略高于非老年组,但差异无统计学意义;自身免疫抗体检验结果显示,PBC患者检出率最高的是AMA、AMA-M2及ANA抗体.老年组中AMA、AMA-M2、Gp210、Spl00的检出率略高于非老年组,ANA的检出率低于非老年组,但差异无统计学意义.结论 老年人原发性胆汁性胆管炎确诊晚,发现时大部分均已进入症状期以后,表现为乏力、黄疸、纳差等,肝硬化、腹水的发生率高.但与非老年组相比差异不显著.

英文摘要:

      Objective To discuss the clinical characteristics of primary billiary cholangistis in elderly patients.Methods 121 patients with primary billiary cholangistis were enrolled in the study:44 cases in elderly group and 78 cases in nonelderly group;the clinicdata of the cases in the 2 groups were collected and analyzed.Results The highest occurrences of clinical symptoms in elderly group were fatigue and jaundice while those in non-elderly group were fatigue and poor appetite,the difference between the 2 groups was of no statistical significance;the average values of TBIL,DBIL,ALT,AST,ALP and GGT of the patients in elderly group were slightly higher than those in non-elderly group,the difference between the 2 groups was of no statistical significance;the detection rates of AMA,AMA-M2,Gp210 and Sp100 in elderly group were slightly higher than those in non-elderly group while the detection rate of ANA in elderly group was lower than that in non-elderly group,the differences between the 2 groups were of no statistical significance.Conclusions The diagnosis of primary billiary cholangistis in the elderly is often confirmed late,usually until the onset of symptoms:fatigue,jaundice and poor appetite,the occurrences of cirrhosis and ascites are high,but there exists no obvious difference between the elderly patients and the non-elderly patients.???