老年脑梗死患者血浆中B型脑钠肽的变化特征及其临床意义

The variation features and clinical significance of B-type natriuretic peptide in Elderly Patients with Cerebral Infarction

中文关键词: 老年  脑梗死  急性  脑钠肽

英文关键词: Elderly  Cerebral infarction (CI)  Acute  B-type natriuretic peptide (BNP)

中文摘要:

      目的 观察老年脑梗死(cerebral infarction,CI)患者血浆中B型脑钠肽(brain natriuretic peptide,BNP)水平的变化特征,探讨BNP在CI中的临床应用意义.方法 选择60例老年CI患者为观察组,58名体检健康者为对照组;60例CI患者依据病程将CI分为急性期(发病3d内)亚组和亚急性期(发病3～ 10d)亚组;60例CI患者根据头颅MRI分型将脑梗死为大面积脑梗死(病灶直径＞5 cm)亚组和非大面积脑梗死(病灶直径≤5 cm)亚组.检测各组和亚组血浆中的BNP水平与进行比较分析.结果 CI组血浆BNP水平显著高于对照组(P＜0.01);CI组急性期亚组血浆BNP含量明显高于对照组(P＜0.01),也显著高于亚急性期亚组(P＜0.01);大面积CI亚组血浆BNP含量显著高于非大面积CI亚组(P＜0.01).结论 急性期和大面积CI老年患者血浆BNP水平明显升高,提示BNP可能在老年CI发生过程中起着重要作用,可望成为CI诊断指标.

英文摘要:

      Objective To discuss the variation features of plasma B-type natriuretic peptide (BNP) in elderly patients with cerebral infarction (CI) and its clinical significance.Methods 60 elderly patients with CI were selected to be observation group while 59 norm???????????????????????????????????????????????????耀??????????耀?????????耀????????怀?耀?????????耀????????????????????????????耀????????????????????耀????????????????????耀???