体质指数对老年乳腺癌新辅助内分泌治疗功效的影响

Impact of BMI on Curative Effect of Neoadjuvant Endocrine Therapy in Elderly Breast Cancer Patients

中文关键词: 体质指数  新辅助内分泌治疗  队列研究

英文关键词: body mass index (BMI)  neoadjuvant endocrine therapy (NET)  cohort study

中文摘要:

      目的 研究体质指数(body mass index,BMI)对激素受体阳性老年乳腺癌患者的新辅助内分泌治疗(NET)功效的影响.方法 回顾性分析研究自1995年1月1日-2014年12月31日在复旦大学附属华东医院诊治的年龄≥65岁,并且接受3个月以上NET的107例激素受体阳性的老年乳腺癌患者临床资料.根据BMI将其分为高BMI组和低/标准BMI组.采用卡方检验分析和比较治疗后2组病理完全缓解率(pCR),客观缓解率(OR)的差异,并运用Kaplan-Meier法和log-rank检验比较无复发生存(RFS)和乳腺癌特异性生存(BCSS)的差异.结果 中位随访6.8年(区间为1.7～10.1年),低/标准BMI组患者治疗后OR率优于高BMI组(OR率64.2％ vs 47.5％,P＜0.05),2组患者的pCR率(7.5％ vs 7.5％,P=0.79),RFS (48.4％ vs 41.1％,HR 95％ CI 0.93 (0.45～1.96),P=0.86)和BCSS (74.0％ vs59.3％ HR 95％CI 0.74 (0.26～2.07),P=0.56)均无统计学差异.结论 BMI对激素受体阳性老年乳腺癌患者内分泌治疗的短期疗效有一定影响,但对于长期生存的影响不明显.

英文摘要:

      Objective To explore the association between body mass index (BMI) and the curative effect of neoadjuvant endocrine therapy (NET) in elderly breast cancer patients with hormone receptor positive.Methods A retrospective analysis was made to the clinical data of 107 elderly breast cancer patients with hormone receptor positive at the age of 65 and over,who were hospitalized in Huadong Hospital during the period from Jan.,1995 to Dec.,31,2014 and received NET for more than 3 months;based on BMI,the patients were divided into 2 groups:high BMI group and low/standard BMI group;pathology complete remission (pCR) rate and objective remission (OR) rate of the patients in the 2 groups after treatment were analyzed and compared with x2 test while the difference in relapse free survival (RFS) and breast cancer specific survival (BCSS) after treatment between the 2 groups were analyzed with Kaplan-Meier and log-rank test.Results The median follow-up was 6.8 years (1.7-10.0);the OR rate of the patients in low/standard BMI group after treatment was superior to that of the patients in high BMI group (64.2％ vs 47.5％,P＜0.05);no statistical difference was found between the 2 groups in pCR rate (7.5％ vs7.5％),RFS [48.4％ vs41.1％,HR95％ CI0.93 (0.45-1.96),P=0.86] andBCSS [74.0％ vs59.3％,HR 95 ％ CI 0.74 (0.26-2.07),P=0.56].Conclusions BMI is of certain impact on short-term curative effect of NET of the elderly breast cancer patients with hormone receptor positive and of no obvious impact on long-term survival.