术前单次口服米诺环素可能降低老年患者术后认知功能障碍的发生率

Preoperative Single Oral Administration of Minocycline in Elderly Patients May Reduce the Incidence of Postoperative Cognitive Dysfunction

中文关键词: 米诺环素  术后认知功能障碍  老年患者

英文关键词: minocycline  postoperative cognitive dysfunction (POCD)  elderly patient

中文摘要:

      目的 探讨围术期应用米诺环素是否能降低65岁及以上老年患者术后认知功能障碍(postoperative cognitive dysfunction,POCD)的发生率.方法 将80例65岁及以上结、直肠癌患者随机分为米诺环素组和对照组,分别于术前2h嘱患者服用米诺环素或者安慰剂0.2g,并在术前1天以及术后第7天对其进行神经心理学测验.利用术后认知功能的评估结果确定围术期应用米诺环素对老年患者术后认知功能的影响.结果 米诺环素组有4例发生POCD,而对照组有1 1例发生POCD,米诺环素组的发病率为10％,对照组的发病率为27.5％,差异有统计学意义.结论 米诺环素可能可以降低老年患者术后认知功能障碍的发生率.

英文摘要:

      Objective To discuss the possibility in reducing the incidence of postoperative cognitive dysfunction (POCD) in the elderly patients of 65 years old and over by perioperative administration of minocycline.Methods 80 elderly patients of 65 years old and over with colon or rectal cancer were randomly divided into 2 groups:minocycline group and control group;2 hours before operation,oral administration of minocycline was made to patients in minocycline group while 0.2g of placebo was given to patients in control group;neuropsychological test was performed on all the patients in both groups 1 day before operation and on the 7th day after operation.Results POCD occurred in 4 patients in minocycline group with the incidence of 10％ while POCD occurred in 11 patients in control group with the incidence of 27.5 ％;the chi-square test indicated that the difference in the incidence of POCD between the 2 groups was of statistical significance.Conclusions Minocycline may reduce the incidence of POCD in elderly patients.