幽门螺杆菌感染与老年2型糖尿病患者动脉粥样硬化的相关性研究

Correlation between Helicobacter Pylori Infection and Atherosclerosis in the Elderly with Type 2 Diabetes

中文关键词: 2型糖尿病  老年  幽门螺旋杆菌  颈动脉内中膜厚度  外周动脉疾病

英文关键词: type 2 diabetes  elderly  helicobacter pylori (Hp)  carotid intima-media thickness (IMT)  peripheral arterial disease (PAD)

中文摘要:

      目的 研究HP感染与老年2型糖尿病患者颈动脉粥样硬化及外周动脉疾病(PAD)的关系.方法 收集413例老年2型糖尿病患者,根据有无Hp感染分为Hp阳性组及Hp阴性组.比较2组血压、血糖、血脂、超敏CRP(hs-CRP)、尿蛋白/肌酐比(ACR)、颈动脉内中膜厚度(IMT)及外周动脉疾病(PAD)发病情况,并行二元Logistic回归分析,探讨Hp感染与动脉粥样硬化的关系.结果 2组在糖尿病病程、血压、血糖,血脂及吸烟等方面比较差异无统计学意义(P＞0.05).Hp阳性组hs-CRP及ACR较Hp阴性组升高且差异有统计学意义(P＜0.05).HP阳性组颈总动脉IMT (0.99±0.38) mm高于Hp阴性组(0.88±0.29) mm (P＜0.01),颈内动脉IMT (0.80±0.29) mm亦高于Hp阴性组(0.74±0.22) mm (P＜0.05).HP阳性组发生PAD比例为48.89％(88/180),多于HP阴性组32.19％(75/233) (P＜0.01).回归分析提示,HP感染为颈总动脉IMT升高(OR=2.33,P＜0.001)及PAD的独立危险因素(OR=2.72,P＜0.001).结论 Hp感染与老年2型糖尿病患者发生颈动脉粥样硬化及PAD有关.

英文摘要:

      Objective To explore the relationship between helicobacter pylori (Hp) infection and carotid atherosclerosis and peripheral arterial disease (PAD) in the elderly patients with type 2 diabetes.Methods 413 elderly patients with type 2 diabetes were selected and divided,according to Hp infection,into 2 groups:positive Hp group and negative Hp group;a comparative study was made to blood pressure,blood glucose,lipid profiles,high-sensitivity CRP (hs-CRP),urine albumin,carotid intima-media thickness (IMT) and the occurrence of PAD between the patients in the 2 groups and binary logistic analysis was performed.Results The comparison of diabetes duration,blood pressure,blood glucose,lipid profiles and smoking rate between the 2 groups was of no statistical difference (P＞0.05);hs-CRP and urine albumin to creatinine raio of the patients in positive Hp group were higher than those of the patients in negative Hp group with statistical difference (P ＜ 0.05);the common carotid artery IMT and internal carotid artery IMT of the patients in positive Hp group:(0.99 ± 0.38) mm and (0.80±0.29) rm,were both higher than those of the patients in negativeHp group:(0.88±0.29) mm and (0.74±0.22) mm,(P＜0.01,P＜0.05);the ratio of PAD occurrence in positive Hp group was 48.89％ (88/180),higher than that in negative Hp group (32.19％,75/233) (P＜0.01);binary logistic analysis indicated that Hp infection was the independent risk factor of increased common carotid artery IMT (OR=2.33,P＜0.001) and of PAD (OR=2.72,P＜ 0.001).Conclusions Hp infection is in certain correlation to carotid atherosclerosis and PAD in the elderly patients with type 2 diabetes.