阿托伐他汀对急性心肌梗死患者血清C-反应蛋白和白细胞介素-1的影响及临床意义

Effects of Atorvastatin on Interleukin-1 and C-reactive Protein Levels of Patients with Acute Myocardial Infarction

中文关键词: 阿托伐他汀  急性心肌梗死  白细胞介素-1  C-反应蛋白  量效反应

英文关键词: atorvastatin  acute myocardial infarction (AMI)  interleukin-1 (IL-1)  C-reactive protein (CRP)  dose-effect relationship

中文摘要:

      目的 观察不同剂量阿托伐他汀对急性心肌梗死(AMI)患者血清C-反应蛋白(CRP)和白细胞介素-1(IL-1)的影响,为明确其量效关系提供参考.方法 80例AMI患者随机分为2组:观察组和对照组,每组40例.对照组口服阿托伐他汀钙片20 mg/晚,观察组口服阿托伐他汀钙片40 mg/晚,2组均服药4周;同时设定40例健康体检者为空白对照组.分别测定各组治疗前后血清CRP和IL-1水平,并进行比较与分析.结果 治疗前观察组和对照组CRP和IL-1水平均明显高于空白对照组(均P＜0.01);治疗后2组患者CRP和IL-1水平明显低于治疗前水平(均P＜0.01),观察组CRP和IL-1水平明显低于对照组(P＜0.01).结论 在AMI患者发病早期使用阿托伐他汀,能够更有效地抑制炎症反应,且有量效关系,可能有助于脂质斑块稳定和预后改善.

英文摘要:

      Objective To observe the effect of different dose of atorvastatin on interleukin-1 (IL-1) and C-reactive protein (CRP) levels of patients with acute myocardial infarction (AMI) so as to provide reference for the determination of the dose-effect relationship.Methods 80 patients with AMI were randomly divided into 2 groups:observation group and control group,40 in each;oral administration of atorvastatin 20 mg per day was made to patients in control group while that of atorvastatin 40 mg per day was made to patients in observation gorup;the course lasted for 4 weeks for both groups;40 norm were selected to be blank control group;detections of CRP and IL-1 levels before and after treatment were performed in each group and the results were compared and analyzed.Results Before treatment,the CRP and IL-1 levels of the patients in observation group and control group were much higher than those in blank control group (P＜0.01);after treatment,the levels of CRP and IL-1 of the patients in both group were obviously lower than those before treatment (P＜0.01) and the levels in observation group were much lower than those in control group (P＜0.01).Conclusions The administration of atorvastatin to patients with early AMI can effectively control the inflammation and the dose-effect relationship may help the stability of lipid plaques and the improvement of prognosis.