老年冠心病血CC类趋化因子配体5和高敏C-反应蛋白水平与冠状动脉粥样硬化程度的相关性研究

Correlation between the Levels of CCL5, hCRP and the Severity of Coronary Atherosclerosis in Elderly Patients with CHD

中文关键词: 老年  冠心病  冠状动脉粥样硬化  CC类趋化因子配体5  高敏C-反应蛋白

英文关键词: elderly  coronary heart disease (CHD)  coronary artery atherosclerosis  CC chemokine ligand-5(CCL5)  high-sensitivity c-reactive protein (hCRP)

中文摘要:

      目的 探讨老年冠心病血浆中CC类趋化因子配体5(CCL5)和高敏C-反应蛋白(hcRP)与冠状动脉粥样硬化程度之间的相关性,为冠心病诊治提供参考.方法 根据临床表现及冠状动脉造影结果,将330例患者分为2组:对照组(n=82)和冠心病组(n=248);根据Gensini积分再将冠心病组分为2个亚组:轻度狭窄组(n=176)和重度狭窄组(n=72).测定并比较各组冠状动脉粥样硬化程度、血CCL5和hs-CRP水平.结果 与对照组比较,冠心病组血浆CCL5及hCRP水平明显升高[(8.9±1.9)ng/mLvs (10.0±1.4) ng/mL,(2.3±1.9)ng/mLvs (5.1±2.2) ng/mL],差异均有统计学意义(均P＜0.05);轻度狭窄组、重度狭窄组血浆CCL5和hCRP水平呈升高趋势;与轻度狭窄组比,重度狭窄组中hCRP和CCL5水平明显升高(P＜0.05,P＜0.01).多重线性回归分析显示,血浆CCL5水平与动脉粥样硬化程度呈独立正相关,P＜0.05.结论 血清CCL5和hCRP能反映冠心病患者冠状动脉狭窄程度,血浆CCL5与冠状动脉粥样硬化程度呈独立正相关,可能成为冠心病诊治的参考指标.

英文摘要:

      Objective To discuss the correlation between the levels of CC chemokine Ligand-5 (CCL5),high-sen-sitivity C-reactive protein (hCRP) and the severity of coronary artery atherosclerosis in elderly patients with coronary heart disease (CHD) so as to provide reference for diagnosis and treatment of CHD.Methods 330 elderly patients with CHD were randomly divided into 2 groups:CHD group (n=248) and control group (n=82) based on the clinical symptoms and the results of coronary arteriography,and the patients in CHD group were further divided into 2 subgroups:mild stenosis group (n=176) and severe stenosis group (n =72);the severity of coronary artery atherosclerosis and the levels of CCL5 and hCRP of the patients in each group were measured and a comparative study was made.Results The levels of CCL5 and hCRP of the patients in CHD group were much higher than those of the patients in control group [(8.9± 1.9) ng/mL vs (10.0± 1.4)ng/mL,(2.3± 1.9) ng/mL vs (5.1 ±2.2) ng/mL],the difference was of statistical significance (P＜0.05);the levels of CCL5 and hCRP of the patients in the 2 sub groups were high while those of the patients in severe stenosis group were even higher than those in mild stenosis group (P＜0.05,P＜0.01);multivariate logistic regression analysis showed that the level of CCL5 was in positive correlation with the severity of coronary artery atherosclerosis,P＜0.05.Conclusions The levels of CCL5 and hCRP may reflect the stenosis of coronary artery atherosclerosis in patients with CHD;the level of CCL5 is in positive correlation with the severity of coronary artery atherosclerosis,which may be taken as a reference in the diagnosis and treatment of CHD.