老年腰痛患者血氧饱和度与骨钙素的相关性研究

Correlation between Blood Oxygen Saturation and Osteocalcin in Elderly LBP Patients

中文关键词: 老年人  血氧饱和度  骨钙素  骨质疏松症

英文关键词: the elderly  blood oxygen saturation (SpO2)  steocalcin (OC)  osteoporosis

中文摘要:

      目的探讨老年腰痛患者血氧饱和度(oxygen saturation, SpO2) 与骨钙素(osteocalcin, OC) 的相关性。方 法随机选取老年腰痛患者137 例，其中男性56 例，女性81 例。检测血气分析和骨代谢四项，包括25-羟基维生素 D、Ⅰ型原胶原N 端前肽（N-terminal propeptide of type I procollagen, PINP）、OC与和-I型胶原C端肽（ C-terminal telopeptide of type I collagen, -CTX）。结果137 例老年患者的SpO2分为正常组（≥95%）和对照组（<95%），2 组 间OC差异有统计学意义（ <0.01）。男性患者的年龄、SpO2与OC呈负相关，且SpO2对OC的影响（b'=-0.404）大 于年龄对OC的影响（b'=-0.331）。女性患者的SpO2与OC 呈负相关（b'=-0.327），但年龄对OC 的影响无统计学意义 （ >0.05）。79~89 岁患者SpO2与OC存在负相关，男性（ =-0.527， <0.05）、女性（ =-0.311， <0.05）。结论低 氧状态下OC较高，因此改善老年人的呼吸状态，可能是防治老年人骨质疏松症的一种方法。

英文摘要:

      Objective To explore the correlation between blood oxygen saturation (SpO2) and osteocalcin (OC) in elderly low back pain (LBP) patients. Methods 137 elderly LBP patients were selected, including 56 male and 81 female;blood gas analysis and etection of bone metabolism including 25-hydroxy vitamin D, N-terminal propeptide of type I procollagen (PINP), OC and C-terminal telopeptide of type I collagen ( -CTX) were performed. Results Out of the 137 elderly patients, some with SpO2≥95% formed the normal group and some with SpO2<95% formed the control group while there existed a statistical difference in OCbetween the 2 groups ( <0.01); age and SpO2 of male patients were in negative correlation with OC and SpO2 (b'=-0.404) had a greater effect than age (b'=-0.331) on OC; SpO2 of the female patients was in negative correlation with OC (b'=-0.327) while age was of no statistical effect on OC ( >0.05); SpO2 of the patients at the age from 79 to 89 was in negative correlation with OC ( male: =-0.527, female: =-0.311, <0.05). Conclusions The level of OC is high under hypoxia, thus, to improve the respiration of the elderly may be a way to prevent osteoporosis in the elderly.