胸部CT扫描测定肺动脉与主动脉直径比值与老年COPD患者血清炎症因子的相关性研究

Correlation between PA∶ A Ratio Measured by Chest CT Scan and Serum Inflammatory Factors in Elderly Patients with COPD

中文关键词: 老年  慢性阻塞性肺疾病  胸部CT扫描  PA∶A比值

英文关键词: elderly  chronic obstructive pulmonary disease (COPD)  chest CT scan  pulmonary artery diameter to aortic diameter (PA∶ A)

中文摘要:

      目的 研究动态测定肺动脉与主动脉直径比值(PA∶A)与老年COPD患者血清炎症因子的相关性.方法 选取慢性阻塞性肺疾病急性加重(AECOPD)患者90例,根据胸部CT扫描测定,PA∶ A≤1为A组(45例),PA∶ A＞1为B组(45例),同时行超声心动图、肺功能检查,并测定血清IL-6、IL-21和TNF-α水平,记录2组患者入院时、出院时、出院后6个月和12个月的临床资料及12个月内患者急性加重次数及死亡患者数目.结果 B组患者1年内急性加重的次数及死亡率明显高于A组.2组患者的PA∶A比值、PASP和FEV 1％的差异以及血清IL-6、IL-21和TNF-α的差异均有统计学意义(P＜0.05).且PA∶A比值与PASP、血清IL-6、IL-21和TNF-α呈正相关,与FEV1％呈负相关(P＜0.05).结论 胸部CT扫描测定PA∶A比值与血清IL-6、IL-21和TNF-α水平有一定的相关性.

英文摘要:

      Objective To study thecorrelation between the ratio of pulmonary artery diameter to aortic diameter (PA∶ A) and serum inflammatory factors measured dynamically in elderly patients with chronic obstructive pulmonary disease (COPD).Methods 90 cases with acute exacerbation chronic obstructive pulmonary disease (AECOPD) were enrolled and divided,according to chest CT scan,into 1 groups:group A (n=45,PA∶ A≤1) and group B (n=45,PA∶ A＞1);echocardiography and pulmonary function test were made to cases in both groups and the levels of serum IL-6,IL-21 and TNF-α were detected;the clinical data of all the cases were recorded,including admission and discharge time,follow-up for 6 and 12 months,acute exacerbation time and the number of death within12 months after discharge.Results The acute exerbation times and the number of death within12 months after discharge in group B were more and bigger than those in group A;there existed a statistical difference in PA∶ A raito,PASP,FEV1％ and the levels of serum IL-6,IL-21 and TNF-α between the 2 groups (P＜0.05);PA∶ A ratio was in positive correlation to PASP and the levels of serum IL-6,IL-21 and TNF-α but in negative correlation to FEV1％ in both groups (P＜0.05).Conclusions There exists a certain correlation between PA∶A ratio measured by chest CT scan and the levels of serum IL-6,IL-21 and TNF-α.