血脂成分与冠状动脉病变狭窄程度的相关性研究

Correlation between Lipid Composition and the Severity of Coronary Artery Lesions

中文关键词: 血脂成分  载脂蛋白B  冠状动脉粥样硬化性心脏病  Gensini积分

英文关键词: lipid composition  apolipoprotein B  coronary heart disease  Gensini score

中文摘要:

      目的 研究血脂成分与冠状动脉病变程度的相关性.方法 对511例反复发作胸闷、胸痛,拟诊冠心病的住院患者行冠状动脉造影,使用Gensini积分评估冠状动脉病变程度,并与血脂成分及其他血生指标及危险因素进行统计分析.结果 不同Gensini积分组间的HDL(P＜0.001)、apoA (P=0.012)、TC/HDL (P=0.012)、LP (a) (P=0.006)、apoA/HDL (P=0.040)、apoB/HDL (P=0.004)、LDL/HDL (P=0.004)、TG/HDL (P=0.027)、NHDL/apoB (P=0.044)不同,差异有统计学意义;多元线性回归分析提示apoB/LDL-C (P＜ 0.001)、肌钙蛋白T(P＜0.001)和LDL-C/HDL-C(P=0.008)与冠脉病变严重程度关系密切.结论 冠状动脉病变程度与异常血脂成分有关,apoB/LDL-C对冠心病的预测作用可能优于其他血脂指标及脂质成分组合.

英文摘要:

      Objective To explore the correlation between the lipid composition and the severity of coronary artery lesions.Methods Coronary angiography was made to 511 suspected coronary artery disease in-patients with repeated occurrence of chest distress and chest pain,and Gensini score was applied in estimating the severity of coronary artery lesions,the scores,as well as the lipid compositions,other blood biochemical indicators and risk factors were statistically analyzed.Results Patients with different Gensini scores had different HDL (P＜ 0.01),LDL/HDL (P=0.004),TG/HDL (P=0.027) and NHDL/ apoB (P=0.044),the difference was of statistical significance;multiple linear regression analysis showed that apoB/LDL-C (P＜0.001),cTnT (P＜0.01) and LDL-C/HDL-C (P=0.008) were closely correlated to the severity of coronary artery lesions.Conclusions The severity of coronary artery lesion is correlated to dyslipidemia and apoB/LDL-C might be superior in predicating coronary heart disease to other lipid indicators and lipid compositions.