β2微球蛋白的升高在急性心梗中预测死亡风险的临床意义

Mortality Predicting Value of Increased Beta2-microglobulin Level in Acute Myocardial Infarction

中文关键词: p2微球蛋白  心肌梗死预后  心血管疾病

英文关键词: bate2-microglobulin (β2m)  myocardial infarction  prognosis  cardiovascular diseases

中文摘要:

      目的 测定急性心肌梗死(AMI)后β2微球蛋白(β2m)的水平变化,评估其对于心梗后临床不良事件的发生是否具有预测价值.方法 入选急性心梗患者126例,正常体检126例.用Elisa法测定其血浆中β2m的值,同时采集了生化及心超临床指标.对于不良临床事件(ACO)进行2年的随访.结果 急性心梗后β2m明显升高(P＜0.0001),其具有独立的心梗后ACO风险预测能力(P=0.002).β2m与心超LVEF值呈负相关(P=0.026),与高血压危险分层(P=0.002)、心梗面积(P=0.003)和左室壁运动指数(P=0.016)呈正相关.结论 心梗后患者血清β2m水平明显升高,其可能具有独立预测心梗后死亡风险的临床价值.

英文摘要:

      Objective To detect the changes of bate2-microglobulin (β2m) level after acute myocardial infarction (AMI) and to assess its value in predicting the risk of adverse clinical outcome (ACO) after AMI.Methods 126 cases with AMI and 126 norm of physical examination were enrolled;ELISA was applied in detecting the value of plasma β2m and the clinical data including biochemical examinations and echocardiography were collected;follow-up of ACO lasted for 2 years.Results Plasma β2m increased significantly after AMI (P＜0.0001) and it was of independent risk prediction of ACO after AMI (P=0.002);β2m was negatively correlated with left ventricular ejection fraction (LVEF) of echocardiography (P=0.026) while positively correlated with hypertension risk stratification (P=0.002),the size of infarction area (P=0.003) and the index of left ventricular wall motion (P=0.016).Conclusions The plasma β2m level increases significantly after AMI,it may be of certain clinical value in predicting independently the mortality risk after AMI.