年龄相关性黄斑变性与外周血血脂水平相关性的Meta分析

Correlation between Age-related Macular Degeneration and Levels of Peripheral Blood Lipid: A Meta-analysis

中文关键词: 血脂异常  胆固醇  黄斑变性  Meta分析

英文关键词: dyslipidemia  cholesterol  macular degeneration  Meta-analysis

中文摘要:

      目的 系统评价外周血血脂水平与年龄相关性黄斑变性(age-related macular degeneration,AMD)的相关性.方法 计算机检索Web of science、PubMed、Embase、中国知网、万方数据及维普中文科技期刊数据库,检索时限为1990年1月-2017年2月.此外手工检索相关文献,并对纳入的文献进行筛选、提取和分析数据,并对纳入文献进行异质性、偏倚风险及质量评价.采用Comprehensive Meta analysis version 2.2.064软件对AMD组和对照组外周血低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和三酰甘油(triglycerides,TG)水平进行Meta分析.结果 本研究最终纳入15篇文献,包括8456例研究对象,其中AMD组4 816例、对照组3 640例.Meta分析结果显示,AMD组TC (MD[均数差]=0.395,95％CI=0.048～0.734,P＜0.05)、LDL-C (MD=0.283,95％CI=0.131～0.435,P＜0.05)、TG(MD=0.247,95％ CI =0.042 ～ 0.452,P＜0.05)水平均高于对照组,差异有统计学意义.AMD组和对照组HDL-C水平差异无统计学意义(MD=-0.018,95％ CI =-0.072 ～ 0.036,P=0.521).漏斗图及Egger检验结果均未显示纳入的文献存在明显的发表偏倚.结论 AMD患者外周血TC、LDL-C和TG水平升高,提示外周血血脂水平异常与AMD存在密切相关性.

英文摘要:

      Objective To make a systematic analysis of the correlation between age-related macular degeneration (AMD) and the levels of peripheral blood lipid.Methods Computer literature retrial was made in databases including Web of science,Pubmed,Embase,China National Knowledge Infrastructure (CNKI),Wanfang Database and VIP Database of Chinese Journal (from Jan.,1990 to Feb.,2017) combined with manual retrieval;screening,extraction and data analysis were performed on all the included literatures as well as the evaluation of heterogenicity,bias risk and quality;the levels of low density lipoprotein cholesterol (LDL-C),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) in AMD and in control group were analyzed by Comprehensive Meta analysis (Version 2.2.064).Results A total of 15 articles were included and the total sample size was 8 456 cases,including 4 816 patients with AMD and 3 640 normal control subjects;the Meta analysis showed that the level of TC (MD=0.395,95％CI=0.048-0.734,P＜0.05),LDL-C (MD=0.283,95％CI=0.131-0.435,P＜0.05),and triglycerides (TG) (MD=0.247,95％CI=0.042-0.452,P＜0.05) were all higher in AMD group than those in control group;there existed no difference of statistical significance in the level of HDL-C between AMD and normal control (MD=-0.018,95％CI=-0.072-0.036,P=0.521);no obvious publication bias was detected by the funnel and Egger test.Conclusions The increase of the levels of TC,LDL-C,and TG in AMD patients suggests a close correlation between dyslipidemia and the onset/development of AMD.