酒石酸美托洛尔联合胺碘酮治疗对老年冠心病合并心律失常患者心脏功能及血流动力学的影响

Effect of metoprolol tartrate combined with amiodarone on cardiac function and hemodynamics in elderly patients with coro-nary heart disease complicated with arrhythmia

中文关键词: 老年  冠心病合并心律失常  酒石酸美托洛尔  胺碘酮  心脏功能  血流动力学  不良反应

英文关键词: elderly  coronary heart disease complicated with arrhythmia  metoprolol tartrate  amiodarone  heart func-tion  hemodynamics  adverse reaction

中文摘要:

      目的 观察酒石酸美托洛尔与胺碘酮联合治疗对老年冠心病合并心律失常患者心脏功能、血流动力学及不良反应的影响,为治疗该病症提供方法.方法 选择2019 年1 月—2022 年7 月于中国人民解放军西部战区总医院诊治的老年冠心病合并心律失常患者96 例,根据不同治疗方案分为观察组(n =50)和对照组(n =46).对照组患者采用胺碘酮治疗,观察组患者采用酒石酸美托洛尔联合胺碘酮治疗,2 组均持续治疗 1 个月.结果 观察组总疗效明显高于对照组(90.00%vs 71.74%,P＜0.05).与同组治疗前比较,治疗后2 组室性期前收缩及心率均显著降低,2 组LVEF、LVESV值均升高,且观察组室性期前收缩及心率均低于对照组,LVEF、LVESV值高于对照组,差异均有统计学意义(P＜0.05).2 组治疗后QT间期均长于同组治疗前,但差异均无统计学意义(P＞0.05).治疗后2 组纤维蛋白原、血浆比黏度及血细胞比容指标值均明显低于同组治疗前,且观察组以上指标值均低于对照组(P＜0.05).2 组不良反应轻,不良反应发生率差异无统计学意义(P＞0.05).结论 酒石酸酒石酸美托洛尔联合胺碘酮治疗老年冠心病合并心律失常患者,对患者心脏功能具有一定改善作用,可调节血流动力学的稳定性.

英文摘要:

      Objective To observe the effects of metoprolol tartrate combined with amiodarone on cardiac function and hemodynamics and its adverse reactions in elderly patients with coronary heart disease complicated with arrhythmia, and provide a method for the treatment of this disease. Methods 96 elderly patients with coronary heart disease complicated with arrhyth? mia treated in General Hospital of Western Theatre Command of People??s Liberation Army from January 2019 to July 2022 were selected. According to different treatment regimens, they were divided into observation group (n =50) and control group (n = 46). The control group was treated with amiodarone, while the observation group was treated with metoprolol tartrate combined with amiodarone. Both groups were treated for 1 month. Results The total curative effect of the observation group was signifi? cantly higher than that of the control group (90. 00% vs 71. 74% , P < 0. 05). Compared with the same group before treat? ment, the pre?ventricular contraction and heart rate of the two groups were significantly decreased after treatment, and the LVEF and LVESV values of the two groups were increased; the pre?ventricular contraction and heart rate of the observation group were lower than those of the control group, while the LVEF and LVESV values of the observation group were higher than those of the control group, and the differences were statistically significant (P <0. 05). The QT interval of the two groups after treatment was longer than that of the same group before treatment, but the difference was not statistically significant (P > 0?? 05). After treatment, the index values of fibrinogen, plasma specific viscosity and hematocrit of the two groups were signifi? cantly lower than those of the same group before treatment, and the above index values of the observation group were lower than those of the control group (P < 0. 05). The adverse reactions were mild in both groups, and there was no significant difference in the incidence of adverse reactions between the two groups (P >0. 05). Conclusion The combination of metopro? lol tartrate and amiodarone in the treatment of elderly patients with coronary heart disease complicated with arrhythmia has a cer? tain improvement effect on cardiac function and can regulate the stability of hemodynamics.