老年肿瘤合并脑梗死患者血清ACL、抗β2GP1、Hcy、hs-CRP的增龄性变化及临床意义

Age-related changes and clinical significance of serum ACL,anti-β2GP1,Hcy and hs-CRP in elderly tumor patients with cere-bral infarction

中文关键词: 老年  肿瘤  脑梗死  抗心磷脂抗体  抗β2糖蛋白1  同型半胱氨酸  超敏C反应蛋白

英文关键词: elderly  tumor  cerebral infarction  anti-cardiolipin antibody  anti-beta 2 glycoprotein 1  homocysteine  hypersensitive C-reactive protein

中文摘要:

      目的 探究老年肿瘤合并脑梗死患者血清抗心磷脂抗体(ACL)、抗 β2 糖蛋白 1(β2GP1)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)的增龄性变化及临床意义.方法 回顾性分析2020 年2 月—2022 年12 月沧州市人民医院收治的112 例老年肿瘤合并脑梗死的患者临床资料,以 10 岁为年龄段将研究对象分为A组(60～,n =49)、B组(70～,n =40)、C组(80～,n =23),并选取年龄和性别匹配的非肿瘤患者作为对照组.测定4 组血清ACL、抗β2GP1、Hcy、hs-CRP水平与阳性率,并进行比较;采用Spearman相关性方法分析年龄与血清ACL、抗β2GP1、Hcy、hs-CRP水平的相关性.结果 A组、B组、C组患者血清ACL、抗β2GP1、hs-CRP水平差异有统计学意义(P＜0.05),而Hcy差异无统计学意义(P＞0.05),对照组血清ACL、抗β2GP1、Hcy、hs-CRP水平均低于A组、B组、C组(P＜0.05);A组hs-CRP阳性率(30.61%)显著低于B组(55.00%)与C组(73.91%)(P＜0.05);A组、B组、C组ACL、抗β2GP1、Hcy阳性率差异无统计学意义(P＞0.05),对照组血清 ACL、抗 β2GP1、Hcy、hs-CRP阳性率均低于 A组、B 组、C 组(P＜0.05);Spearman相关性分析结果显示,老年肿瘤合并脑梗死患者年龄与ACL、抗β2GP1 呈负相关(P＜0.05),与hs-CRP呈正相关(P＜0.05),与不良嗜好、肿瘤类型及Hcy无相关性(P＞0.05).结论 老年肿瘤合并脑梗死患者不同年龄阶段血清ACL、抗β2GP1、hs-CRP水平存在差异,ACL、抗β2GP1 呈下降趋势,hs-CRP水平呈上升趋势,且老年肿瘤合并脑梗死患者的年龄与血清ACL、抗β2GP1、hs-CRP水平存在显著相关性,临床可通过检测ACL、抗β2GP1、hs-CRP水平对患者病情及疾病进展情况进行判定,以便及时采取措施进行治疗.

英文摘要:

      Objective To investigate the age?related changes and clinical significance of serum anti?cardiolipin antibody (ACL), anti?beta 2 glycoprotein 1 antibodies (β2GP1), homocysteine (Hcy) and hypersensitive C?reactive protein (hs?CRP) in elderly tumor patients with cerebral infarction. Methods The clinical data of 112 elderly tumor patients with cerebral infarc? tion admitted to People??s Hospital of Cangzhou City from February 2020 to December 2022 were analyzed retrospectively. They were divided into group A (49 patients aged 60?), group B (40 patients aged 70?) and group C (23 patients aged 80?). Addi? tionally, age—and gender—matched patients without tumors were selected as the control group. The levels and positive rates of serum ACL, anti?β2GP1, Hcy and hs?CRP in the four groups were measured and compared. Results There were statistically significant differences in the levels of serum ACL, anti?β2GP1 and hs?CRP among the group A, group B and group C (P < 0?? 05), but there was no statistically significant difference in Hcy level among the three groups (P >0. 05). The levels of serum ACL, anti?β2GP1, Hcy and hs?CRP of the control group were lower than those of the other three groups (P <0. 05). The posi? tive rate of hs?CRP in the group A was 30. 61% , significantly lower than that in the group B (55. 00% ) and the group C (73. 91% ) (P < 0. 05). There was no statistically significant difference in the positive rates of ACL, anti?β2GP1 and Hcy among group A, group B and group C (P >0. 05). The positive rates of ACL, anti?β2GP1, Hcy and hs?CRP in the control group were lower than those in the other three groups (P <0. 05). Spearman correlation analysis results showed that age of elderly tumor pa? tients with cerebral infarction was negatively correlated with ACL and anti?β2GP1 (P <0. 05), and positively correlated with hs? CRP (P <0. 05). However, there was no significant correlation with bad habits, tumor type and Hcy (P >0?? 05). Conclusion There were differences in the levels of serum ACL, anti?β2Gp1 and hs?CRP in elderly tumor patients with cerebral infarction at different ages. The levels of serum ACL and anti?β2Gp1 showed a decreasing trend, while hs?CRP level showed an increasing trend, and there was a significant correlation between age and the levels of serum ACL, anti?β2Gp1 and HS?CRP in elderly tumor patients with cerebral infarction. Clinically, detection of the levels of serum ACL, anti?β2GP1, hs?CRP can be used to determine the patient??s condition and disease progression, so as to take treatment measures in time.