老年人群幽门螺杆菌感染与肺磨玻璃结节相关性研究

A study on the correlation between Helicobacter pylori infection and pulmonary ground-glass nodules in elderly population

中文关键词: 老年  肺磨玻璃结节  幽门螺杆菌感染  发生率

英文关键词: elderly  pulmonary ground-glass nodule  Helicobacter pylori infection  incidence

中文摘要:

      目的 探讨上海地区老年体检人群中幽门螺杆菌(Helicobacter pylori,Hp)感染与肺磨玻璃结节间的相关性.方法 回顾性分析2021 年1 月—12 月在复旦大学附属华东医院体检中心接受常规体检的老年人群7 587 例,根据其Hp感染和肺磨玻璃结节的检出情况,进行分组:Hp感染组和非感染组;肺磨玻璃结节组和无结节组.分别统计不同性别的人群两者检出率的差异,再进一步分析肺磨玻璃结节组和无结节组间一般资料、血常规、肿瘤标志物等资料和Hp阳性率的差异;并观察其中1 289 例年龄≥75 岁的老年人群,在肺磨玻璃结节组与无结节组间Hp阳性率的差异.结果 年龄≥60 岁和≥75 岁人群中,老年女性肺磨玻璃结节检出率均高于老年男性(21.50%vs 15.04%;20.14%vs 14.66%),老年男性Hp阳性率均高于老年女性(26.74%vs 21.64%;28.08%vs 22.97%),差异均有统计学意义(P＜0.05).年龄≥60岁和≥75 岁人群中,肺磨玻璃结节组的Hp阳性率均低于无结节组(22.63%vs 24.74%;23.18%vs 26.38%),虽无统计学意义,但2 组人群中均能观察到在肺磨玻璃结节组中Hp阳性率较无结节组有下降趋势.在年龄≥60 岁人群中进一步分析,肺磨玻璃结节组的NSE高于无结节组;老年男性比例、WBC、Hb低于无结节组,差异均有统计学意义(P＜0.05).结论 老年人群中肺磨玻璃结节形成的原因是多方面的,而Hp感染可能会一定程度抑制肺磨玻璃结节的发生.

英文摘要:

      Objective To investigate the correlation between Helicobacter pylori(Hp)infection and pulmonary ground-glass nodules(GGN)in elderly population undergoing physical examinations in Shanghai.Methods A retrospective analysis was performed on 7 587 elderly patients who received routine physical examination in Health Examination Center of Huadong Hospital Affiliated to Fudan University from January to December 2021.According to the status of Hp infection and GGN,the patients were divided into Hp infection group and non-infection group;GGN group and non-GGN group.The differ-ence of detection rate between male and female groups was statistically analyzed,and then the difference was analyzed in gener-al data,blood routine test,tumor markers and Hp positive rate between GGN group and non-GGN group.The difference in Hp positive rate between the GGN group and non-GGN group was observed in 1 289 subjects aged≥75 years.Results In people aged≥60 and≥75 years,the detection rates of GGN in elderly women were both higher than those in elderly men(21.50%vs 15.04%;20.14%vs 14.66%),and the Hp positive rate in elderly men were both higher than those in elderly women(26.74%vs 21.64%;28.08%vs 22.97%),the differences were statistically significant(P＜0.05).In people aged≥60 and≥75 years,the Hp positive rate in the GGN group were both lower than those in the non-GGN group(22.63%vs 24.74%;23.18%vs 26.38%).Although there was no statistical significance,a downward trend in Hp positive rate was observed in both groups compared to the non-GGN group.Further analysis in the subjects aged 60 years and above showed that neuron specific enolase(NSE)in the GGN group was higher than that in the non-GGN group,the proportion of elderly men,WBC and Hb were lower than those in the non-GGNgroup,and the differenceswere statistically significant(P＜0.05).Conclusion There are many rea-sons for the formation of GGN in the elderly patients,and Hp infection may inhibit the occurrence of GGN to a certain extent.