双向孟德尔随机化研究分析哮喘与肌少症的因果效应

Causal effect between asthma and sarcopenia:a bidirectional Mendelian randomization study

中文关键词: 哮喘  肌少症  孟德尔随机化研究  握力

英文关键词: asthma  sarcopenia  Mendelian randomization study  grip strength

中文摘要:

      目的 采用孟德尔随机化研究(MR)探索哮喘与肌少症的因果效应.方法 两样本MR评估哮喘数据集对肌少症关联的3 个数据集(低手握力、四肢肌肉重量和行走速度)的因果关系.逆方差加权法结果作为主要指标,MR-Egger 回归、加权中位值、基于众数的简单估计和基于众数的加权估计作为参考.逐步剔除法检验敏感性,Q检验检验异质性,MR-pleiotropy函数检验多效性.反向MR研究肌少症对哮喘的影响.结果 哮喘与低手握力概率增加有关(OR =1.703,95%CI:1.206～2.405,P =0.003);与四肢肌肉重量减少有关(OR =0.733,95%CI:0.598～0.899,P =0.003);与行走速度降低有关(OR =0.930,95%CI:0.873～0.990,P =0.022).逐步剔除法证实哮喘对肌少症3 个数据集因果效应结果稳定.反向研究未发现肌少症对哮喘存在促进作用.结论 哮喘促进肌少症的发生和发展,是肌少症的潜在不利因素.

英文摘要:

      Objective To explore the causal effect between asthma and sarcopenia by means of a Mendelian randomiza-tion(MR)study.Methods Two-sample MR method was used to evaluate the causal relationship between asthma dataset and three datasets associated with sarcopenia(low hand grip strength,limb muscle weight,and walking speed).The results of in-verse variance weighting method were used as the main indicators,and the MR-Egger regression,weighted median value,sim-ple mode-based estimation and mode-based weighted estimation were used as the references.The stepwise elimination method was used to test sensitivity,the Q test was used to test heterogeneity,and the MR pleiotropy function was used to test pleiotro-py.The reverse MR study was conducted to investigate the effect of sarcopenia on asthma.Results Asthma was associated with an increased probability of low hand grip strength(OR =1.703,95% CI:1.206-2.405,P =0.003),decreased limb muscle weight(OR = 0.733,95% CI:0.598-0.899,P =0.003),and decreased walking speed(OR = 0.930,95% CI:0.873-0.990,P =0.022).The stepwise elimination method confirmed that the causal effect of asthma on the 3 datasets of sar-copenia was stable.The reverse study did not find any promoting effect of sarcopenia on asthma.Conclusion Asthma pro-motes the occurrence and development of sarcopenia,and is a potential adverse factor for sarcopenia.