丁苯酞联合奥扎格雷对老年急性脑梗死患者神经功能、炎性因子及预后的影响

Effects of combination of butylphthalide and ozagrel on neurological function,inflammatory factors,and prognosis in elderly patients with acute cerebral infarction

中文关键词: 老年  丁苯酞  奥扎格雷  急性脑梗死  神经功能  预后

英文关键词: elderly  butylphthalide  ozagrel  acute cerebral infarction  neurological function  prognosis

中文摘要:

      目的 探讨丁苯酞联合奥扎格雷对老年急性脑梗死(ACI)患者神经功能、炎性因子及预后的影响.方法 回顾性分析2020 年10 月—2023 年10 月在安徽医科大学附属安庆第一人民医院神经内科接受治疗的 120 例ACI患者资料,所有患者接受常规治疗后,根据不同用药方案分为2 组,对照组(n =58)给予静脉注射奥扎格雷,观察组(n =62)在对照组的基础上给予丁苯酞注射液.比较2 组疗效、治疗前后神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)、中枢神经特异性蛋白β(S100β)、人血浆脂蛋白磷脂酶A2(Lp-PLA2)、白介素-6(IL-6)、Barthel指数(BI)量表、改良Rankin量表(mRS)评分变化及2 组不良反应发生情况.结果 观察组治疗疗效高于对照组(87.10%vs 70.69%,P＜0.05).治疗后,2 组脑损伤标志物NSE、GFAP、S100β、炎症因子Lp-PLA2、IL-6 水平及mRS评分较治疗前均降低,且观察组显著低于对照组(P＜0.05).治疗后,2 组BI评分高于治疗前,且观察组显著高于对照组(P＜0.05).观察组不良反应发生率与对照组比较差异无显著性(11.29%vs 8.62%,P＞0.05).结论 丁苯酞联合奥扎格雷治疗ACI患者的临床疗效显著,能减轻患者神经功能损伤,同时降低炎性反应,有利于患者的预后.

英文摘要:

      Objective To study the effects of butylphthalide combined with ozagrel on neurological function,inflamma-tory factors and prognosis in elderly patients with acute cerebral infarction(ACI).Methods The data of 120 ACI patients who received treatment in Department of Neurology,Anqing First People's Hospital Affiliated to Anhui Medical University from October 2020 to October 2023 were retrospectively analyzed.After receiving routine treatment,all patients were divided into two groups according to different medication regimens.The control group(n =58)was given intravenous injection of oza-gre,and the observation group(n =62)was given butylphthalide injection on the basis of the control group.The therapeutic ef-ficacy,the levels of neuron-specific enolase(NSE),glial fibrinoacidic protein(GFAP),central nervous specific protein β(S100β),human plasma lipoprotein phospholipase A2(Lp-PLA2),interleukin-6(IL-6),and the scores of Barthel Index(BI)and modified Rankin Scale(mRS)before and after treatment,as well as the incidence of adverse reactions were com-pared between the two groups.Results The therapeutic efficacy of the observation group was higher than that of the control group(87.10%vs70.69%,P＜0.05).After treatment,the levels of brain injury markers(NSE,GFAP,S100β)and in-flammatory factors(Lp-PLA2 and IL-6)and mRS scores in both groups were decreased compared with before treatment,and the observation group was significantly lower than the control group(P＜0.05).After treatment,BI score was higher than that of the same group before treatment,and the observation group was significantly higher than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(11.29%vs8.62%,P＞0.05).Conclusion The combination of butylphthalide and ozagrel has a significant clinical effect in the treatment of ACI patients.It can alleviate the neurological function damage and inflammatory response of patients,and is conducive to the prognosis of patients.