老年慢性阻塞性肺疾病稳定期患者外周血CircDCUN1D4的水平及临床意义

The level and clinical significance of CircDCUN1D4 in peripheral blood of elderly COPD patients

中文关键词: 老年  慢性阻塞性肺疾病  CAT评分  第一秒用力肺活量占预计值的百分比  外周血  CircDCUN1D4

英文关键词: elderly  chronic obstructive lung disease  CAT score  FEV1pred  peripheral blood  CircDCUN1D4

中文摘要:

      目的 检测慢性阻塞性肺疾病(COPD)患者外周血CircDCUN1D4的水平,探讨circDCUN1D4在COPD中的作用及临床意义.方法 选取2022年11月1日—2023年4月30日在上海市第六人民医院金山分院呼吸科就诊的老年COPD稳定期患者40例(设为观察组),以同期院40例体检中心年龄和性别匹配的老年体检健康者为对照组.对COPD患者进行慢阻肺评估测试(CAT评分)、肺功能检查,记录FEV1/FVC及FEV1pred％;检测并比较2组外周血CircD-CUN1D4 的表达水平.将COPD患者分为60～80岁亚组(n=24)及 年龄≥80岁亚组(n=16),对比分析2亚组CAT评分、FEV1 pred％及外周血circDCUN1D4水平的差异.结果 COPD患者外周血CircDCUN1D4表达水平(3.47±1.55)高于健康对照组(1.15±0.56),组间差异有显著统计学意义(P＜0.01);年龄≥80岁组患者circDCUN1D4水平、CAT评分高于60～80岁组,FEV1 pred％低于60～80岁组,差异均有统计学意义(P＜0.05).结论 老年COPD稳定期患者外周血circDCUN1D4水平的变化可能与COPD发病、病情发展有关;通过检测外周血circDCUN1D4表达水平,有可能作为COPD早期诊断、预后评估的潜在指标.

英文摘要:

      Objective To detect the level of peripheral blood CircDCUN1D4 in patients with chronic obstructive pulmo-nary disease(COPD),and explore its role and clinical significance in COPD.Methods 40 elderly patients with stable COPD who were admitted to Department of Respiratory Medicine,Jinshan Branch of Sixth People's Hospital of Shanghai City from November 1,2022 to April 30,2023 were selected(observation group).Another 40 elderly healthy individuals who underwent physical examinations in Medical Examination Center of the hospital during the same period were selected(control group).The chronic obstructive pulmonary disease assessment(CAT score)and lung function examination were performed on COPD pa-tients,and their FEV1/FVC and FEV1pred％were recorded.The expression levels of CircDCUN1D4 in peripheral blood of the two groups were detected and compared.COPD patients were divided into 60-80 years old subgroup(n=24)and ≥80 years old subgroup(n=16).The differences in CAT score,FEV1pred％and peripheral blood circDCUN1D4 level were analyzed and compared between the two subgroups.Results The expression level of peripheral blood CircDCUN1D4(3.47±1.55)of the observation group was higher than that of the control group(1.15±0.56),with statistically significant(P＜0.01).The circDCUN1D4 level and CAT score of the ≥ 80 years old subgroup were higher than those of the 60-80 years old subgroup,and the FEV1pred％was lower than that of the 60-80 years old subgroup.The differences between the two subgroups were statisti-cally significant(P＜0.05).Conclusion The changes of peripheral blood circDCUN1D4 level of elderly patients with stable COPD may be related to the onset and progression of COPD.The expression level of peripheral blood circDCUN1D4 may be a potential indicator for the early diagnosis and prognosis evaluation of COPD.