瑞舒伐他汀联合阶段性功能锻炼对老年冠心病患者的疗效及心功能水平的影响

Effects of rosuvastatin combined with periodic functional exercise on efficacy and cardiac function in elderly patients with coro-nary heart disease

中文关键词: 老年  冠心病  瑞舒伐他汀  心功能

英文关键词: elderly  coronary heart disease  rosuvastatin  cardiac function

中文摘要:

      目的 探究瑞舒伐他汀联合阶段性功能锻炼对老年冠心病患者的疗效及心功能水平的影响,旨在为其临床诊治和预后判断提供依据.方法 选取于2020年1月—2022年12月收治于阜阳市人民医院的老年冠心病患者110例,通过随机数字表法分为观察组(n=55)和对照组(n=55),剔除未按时间随访及相关检验指标明显异常者,最终观察组纳入51例患者,对照组纳入50例患者.对照组给予调脂、抗血小板及常规康复训练,观察组在与对照组相同治疗的基础上联合瑞舒伐他汀及阶段性功能锻炼,2组患者均连续治疗6周.观察并比较2组治疗前后左心室射血分数(LVEF)及左心室舒张末期内径(LVEDD)等心功能指标值;通过简明生活质量量表(SF-36)评价并对比2组生活质量,通过简易疾病感知问卷(BIPQ)评价并对比2组对疾病的认知情况,通过一般自我效能感量表(GSES)评价并对比2组的自我效能感;比较2组治疗前后血清总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)水平、临床疗效及治疗期间不良反应发生情况.结果 治疗后,2组心绞痛发病次数、持续时间均低于同组治疗前,观察组患者心绞痛发病次数、持续时间均低于对照组(均P＜0.05).2组患者SF-36、BIPQ及GSES评分均高于同组治疗前,观察组SF-36、BIPQ及GSES评分均高于对照组(均P＜0.05).2组患者TC、TG及LDL-C水平均低于同组治疗前,观察组TC、TG及LDL-C水平均低于对照组(均P＜0.05).2组患者LVEF水平高于同组治疗前,观察组LVEF水平高于对照组,而2组LVEDD水平低于同组治疗前,观察组LVEDD水平低于对照组(均P＜0.05).观察组治疗总有效率高于对照组(92.16％vs78.00％,P＜0.05).观察组患者治疗不良反应发生率低于对照组(7.84％vs 12.00％),但差异无统计学意义(P＞0.05).结论 瑞舒伐他汀联合阶段性功能锻炼应用于老年冠心病患者,可能有效提高患者心功能、改善其生活质量及认知水平、降低血脂紊乱程度、降低不良反应发生率,提示该联合治疗方案有一定的临床应用价值.

英文摘要:

      Objective To investigate the effects of rosuvastatin combined with periodic functional exercise on efficacy and cardiac function in elderly patients with coronary heart disease,and provide the basis for clinical diagnosis,treatment and prognosis.Methods A total of 110 elderly patients with coronary heart disease admitted to People's Hospital of Fuyang City from January 2020 to December 2022 were selected and divided into observation group(n=55)and control group(n=55)by random number table method.After excluding those who did not follow up according to time and their relevant test indexes were obviously abnormal,finally,51 patients were included in the observation group and 50 ones in the control group.The control group was treated with lipid-lowering therapy,antiplatelet therapy,and routine rehabilitation training.The observation group was treated with rosuvastatin and periodic functional exercise on the basis of the same treatment as the control group.Both groups received continuous treatment for 6 weeks.The values of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and other cardiac function indicators were observed and compared between the two groups be-fore and after treatment.The quality of life of the two groups was evaluated and compared by the Concise Quality of Life Scale(SF-36),the disease cognition of the two groups was evaluated and compared by the Simple Disease Perception Questionnaire(BIPQ),and the self-efficacy of the two groups was evaluated and compared by the General Self-Efficacy Scale(GSES).The levels of serum total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)were compared be-tween the two groups before and after treatment.The clinical efficacy and the occurrence of adverse reactions during treatment were compared between the two groups.Results After treatment,the frequency and duration of angina pectoris of both groups were lower than those of the same group before treatment,and the observation group was lower than the control group(all P＜0.05);the scores of SF-36,BIPQ and GSES of both groups were higher than those of the same group before treatment,and the observation group were higher than the control group(all P＜0.05);the levels of TC,TG and LDL-C of both groups were lower than those of the same group before treatment,and the observation group was lower than the control group(all P＜0.05);the LVEF levels of both groups were higher than those of the same group before treatment,and the LVEDD levels of both groups were lower than those of the same group before treatment,while the improvement of above two indexes of the ob-servation group was greater than the control group(all P＜0.05).The total effective rate of the observation group was signifi-cantly higher than that of the control group(92.16％vs 78.00％,P＜0.05).The incidence of adverse reactions in the obser-vation group was lower than that in the control group,but the difference was not statistically significant(7.84％vs 12.00％,P＞0.05).Conclusion Rosuvastatin combined with periodic functional exercise in elderly patients with coronary heart disease may effectively improve the cardiac function of patients,improve their quality of life and cognitive level,reduce the degree of blood lipid disorders,and reduce the incidence of adverse reactions.It is suggested that the combined treatment program has certain clinical application value.