美沙拉嗪联合复方谷氨酰胺治疗老年活动期轻中度溃疡性结肠炎的临床观察

Clinical observation of mesalazine combined with compound glutamine in the treatment of active mild to moderate ulcerative colitis in elderly patients

中文关键词: 老年  溃疡性结肠炎  美沙拉嗪  复方谷氨酰胺  活动期  轻中度  疗效  不良反应

英文关键词: elderly  ulcerative colitis  mesalazine  compound glutamine  active stage  mild to moderate  curative effect  adverse reaction

中文摘要:

      目的 观察美沙拉嗪联合复方谷氨酰胺治疗老年轻中度溃疡性结肠炎(UC)患者的临床效果.方法 选择2020年5月—2023年5月于中国人民解放军东部战区总医院就诊的活动期轻中度老年UC患者106例,按照数表法随机分成观察组和对照组,每组53例.对照组采用美沙拉嗪治疗,观察组在与对照组相同治疗的基础上联合复方谷氨酰胺治疗.比较2组临床疗效、不良反应发生情况;比较2组治疗前、后肠道黏膜屏障功能指标值、血清氧化应激指标值[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平]、炎性因子水平[白细胞介素-23(IL-23)、IL-17水平].结果 治疗后,观察组总有效率明显高于对照组(94.34％vs81.13％,x2=4.496,P=0.038);2组血清D-乳酸、二胺氧化酶水平均低于同组治疗前(P＜0.05),且观察组血清D-乳酸、二胺氧化酶水平均低于对照组(P＜0.05);2组血清GSH-Px、SOD水平均高于同组治疗前(P＜0.05),且观察组GSH-Px、SOD水平均高于对照组(P＜0.05);2组血清MDA、IL-23、IL-17水平均低于同组治疗前(P＜0.05),且观察组血清MDA、IL-23、IL-17水平低于对照组(P＜0.05);2组治疗不良反应发生率差异无统计学意义(13.21％vs9.43％,P＞0.05).结论 相较于美沙拉嗪治疗,美沙拉嗪联合复方谷氨酰胺治疗活动期轻中度UC患者疗效更好.

英文摘要:

      Objective To explore the clinical effects of mesalazine combined with compound glutamine in the treatment of elderly patients with mild to moderate ulcerative colitis(UC).Methods A total of 106 elderly patients with mild to moder-ate UC in active stage treated in General Hospital of Eastern Theater Command from May 2020 to May 2023 were selected and divided into observation group and control group according to the random number table method,with 53 cases in each group.The control group was treated with mesalazine,and the observation group was treated with compound glutamine on the basis of the same treatment as the control group.The clinical efficacy and adverse reactions of the two groups were compared.The in-testinal mucosal barrier function index values,oxidative stress index values[glutathione peroxidase(GSH-Px),superoxide dis-mutase(SOD),malondialdehyde(MDA)],inflammatory factor level[interleukin-23(IL-23),IL-17]before and after treat-ment were compared between the two groups.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(94.34％vs 81.13％,x2=4.496,P=0.038).The levels of D-lactic acid and diamine oxidase of the two groups were lower than those of the same group before treatment(P＜0.05),and the observation group were lower than the control group(P＜0.05).The levels of GSH-Px and SOD of the two groups were higher than those of the same group before treatment(P＜0.05),and the observation group was higher than the control group(P＜0.05).The levels of MDA,IL-23 and IL-17 of the two groups were lower than those of the same group before treatment(P＜0.05),and the obser-vation group was lower than the control group(P＜0.05).There was no significant difference in the incidence of adverse reac-tions between the two groups(13.21％vs 9.43％,P＞0.05).Conclusion Compared with single mesalazine treatment,mesala-zine combined with compound glutamine is more effective in the treatment of patients with active mild to moderate UC.