铝碳酸镁联合艾司奥美拉唑治疗老年胃溃疡的临床分析

Clinical analysis of magnesium aluminate carbonate combined with esomeprazole in the treatment of elderly patients with gas-tric ulcers

中文关键词: 老年  胃溃疡  铝碳酸镁  艾司奥美拉唑  高敏C-反应蛋白  溃疡愈合率  D二聚体

英文关键词: elderly  gastric ulcer  magnesium aluminum carbonate  esomeprazole  hypersensitive c-reactive protein  ulcer healing rate  D-dimer

中文摘要:

      目的 探究铝碳酸镁联合艾司奥美拉唑治疗老年胃溃疡患者疗效及对血清高敏C-反应蛋白(hs-CRP)、血沉(ESR)、D二聚体(D-D)和溃疡愈合率的影响,为治疗该病症提供方法.方法 选取2020年7月—2023年6月在遂宁市中心医院收治的老年胃溃疡患者104例,以随机数字表法分为单药组(艾司奥美拉唑)和联合组(铝碳酸镁联合艾司奥美拉唑),每组52例,2组均治疗4周.比较2组临床症状改善时间及溃疡愈合情况,治疗前和治疗4周后,比较2组血清因子(hs-CRP、ESR、D-D)水平、胃肠道相关指标[胃泌素(GAS)、胃动素(MTL)、内皮素-1(ET-1)]水平、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平.结果 治疗4周后,联合组上腹疼痛、腹胀、发酸、嗳气改善时间均少于单药组(P＜0.05);联合组溃疡愈合率高于单药组(P＜0.05);2组患者溃疡愈合指标(溃疡、底部厚苔、周围再生上皮、周围黏膜充血面积)、血清因子(hs-CRP、ESR、D-D)水平、肠胃功能(GAS、MTL、ET-1)及MDA水平均较同组治疗前降低,联合组上述指标值均低于单药组(均P＜0.05);2组患者SOD水平较同组治疗前升高,联合组SOD水平高于单药组(均P＜0.05).结论 铝碳酸镁联合艾司奥美拉唑可有效改善老年胃溃疡患者临床症状,促进溃疡愈合,缓解炎症反应及氧化应激反应,改善凝血功能及胃肠功能,具有一定的临床应用价值.

英文摘要:

      Objective To explore the effects of magnesium aluminum carbonate combined with esomeprazole in the treatment of elderly patients with gastric ulcer and its effects on serum hypersensitive C-reactive protein(hs-CRP),erythrocyte deposition rate(ESR),D-dimer(D-D)and ulcer healing rate,so as to provide a method for the treatment of this disease.Methods 104 elderly patients with gastric ulcer treated in Central Hospital of Suining City from July 2020 to June 2023 were selected and divided into single drug group(treated with esomeprazole)and combined group(treated with magnesium alumi-num carbonate combined with esomeprazole)by the random number table method,with 52 cases in each group.Both groups were treated for 4 weeks.The improvement time of clinical symptoms and ulcer healing conditions were compared between the two groups.The levels of serum factors(hs-CRP,ESR,D-D),gastrointestinal related indicators[gastrin(GAS),motilin(MTL),endothelin-1(ET-1)]and oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD)]be-fore treatment and after 4 weeks of treatment were compared between the two groups.Results After 4 weeks of treatment,the improvement times of upper abdominal pain,abdominal distension,acid reflux and belching in the combined group were shorter than those in the single drug group(all P＜0.05).The ulcer healing rate in the combined group was higher than that in the sin-gle drug group(P＜0.05).The ulcer healing indicators(ulcer,thick-coated bottom area,surrounding regrowth epithelium ar-ea,surrounding mucosal congestion area),serum factors(hs-CRP,ESR,D-D),gastrointestinal related indicators(GAS,MTL,ET-1)and MDA in the two groups were lower than those of the same group before treatment,and the above indicators in the combined group were lower than those in the single drug group(all P＜0.05).The SOD levels in the two groups were higher than those of the same group before treatment,and the combined group was higher than the single drug group(all P＜0.05).Conclusion The combination of magnesium aluminum carbonate combined with esomeprazole can effectively improve the clinical symptoms of elderly patients with gastric ulcer,promote the ulcer healing,relieve the inflammatory response and oxi-dative stress response,and improve the coagulation function and gastrointestinal function.It has certain clinical application value.