老年代谢相关脂肪性肝病与结直肠腺瘤的相关性研究

A study on relationship between metabolic-associated fatty liver disease and colorectal adenoma in the elderly

中文关键词: 老年  代谢相关脂肪性肝病  结直肠腺瘤  肝纤维化

英文关键词: elderly  metabolic-associated fatty liver disease  colorectal adenoma  hepatic fibrosis

中文摘要:

      目的 探讨老年人群代谢相关脂肪性肝病(MAFLD)、肝纤维化程度与结直肠腺瘤(CRA)的相关性.方法 回顾性分析2021年6月-2022年12月于复旦大学附属华东医院接受腹部超声和电子结肠镜检查的老年患者1 583例,其中男性772例、女性811例,CRA组786例、对照组797例.收集患者的一般资料、血液生化指标和腹部超声结果,二元多因素Logistic回归分析CRA的危险因素,探讨肝纤维化程度与CRA发生风险的相关性.结果 CRA患者MAFLD患病率高于非CRA者(62.98％vs 52.20％).二元多因素Logistic回归分析显示,男性、增龄和MAFLD是CRA发生的危险因素(P＜0.05).APRI≥0.50和FIB4≥2.0是CRA发生的独立危险因素(P＜0.05).结论 老年CRA患者中男性、MAFLD比例较高,随着肝纤维化程度加重,CRA患病风险可能增加.

英文摘要:

      Objective To investigate the relationship between metabolic-associated fatty liver disease(MAFLD)and hepatic fibrosis and colorectal adenoma(CRA)in the elderly.Methods A retrospective analysis was conducted on 1 583 eld-erly patients who underwent abdominal ultrasound and electronic colonoscopy in Huadong Hospital Affiliated to Fudan Universi-ty from June 2021 to December 2022,including 772 males and 811 females,with 786 in the CRA group and 797 in the control group.Their general data,blood biochemical indexes and abdominal ultrasound results were collected.Binary multivariate Lo-gistic regression was used to analyze the risk factors for CRA and the correlation between the degree of liver fibrosis and the risk of CRA was investigated.Results The prevalence of MAFLD in the CRA patients was higher than that in the non-CRA pa-tients(62.98％vs 52.20％).Binary multivariate logistic regression analysis showed that male,increasing age and MAFLD were risk factors for CRA(P＜0.05).APRI score ≥0.50 and FIB-4 score ≥ 2.0 were independent risk factors for CRA(P＜0.05).Conclusion In elderly patients with CRA,the proportion of males and MAFLD is higher.As the degree of liver fibro-sis worsens,the risk of developing CRA may increases.