老年慢加亚急性肝衰竭患者SIRI、SII、肝纤维化水平特征与不良预后的相关性研究

Study on correlation between SIRI,SII,liver fibrosis level and poor prognosis in elderly patients with chronic and subacute liver failure

中文关键词: 老年  慢加亚急性肝衰竭  全身炎症反应指数  预后

英文关键词: elderly  chronic and subacute liver failure  systemic inflammation response index  prognosis

中文摘要:

      目的 探讨老年慢加亚急性肝衰竭患者全身炎症反应指数(SIRI)、系统免疫炎症指数(SII)、肝纤维化水平特征与不良预后的相关性.方法 选取2019年3月-2023年6月期间中国医科大学附属盛京医院收治的105例老年慢加亚急性肝衰竭患者作为研究对象.根据患者治疗后的预后情况划分为预后良好组(n=72)和预后不良组(n=33).比较2组患者全SIRI、SII和肝纤维化4因子指数(FIB-4);通过二元Logistic回归分析筛选老年慢加亚急性肝衰竭患者不良预后的重要危险因素.结果 相比于预后良好组,预后不良组的谷丙转氨酶水平、谷草转氨酶水平、SIRI、SII及FIB-4显著升高,淋巴细胞计数显著降低(均P＜0.05);单因素及多因素Logistic回归分析表明,SIRI、SII、FIB-4升高均是老年慢加亚急性肝衰竭患者的重要危险因素(P＜0.05).结论 SIRI、SII及FIB-4可作为评估老年慢加亚急性肝衰竭患者预后情况的潜在生物学标志物,为进一步构建相关预后风险预测模型提供依据.

英文摘要:

      Objective To investigate the correlation between systemic inflammation response index(SIRI),systemic immune-inflammation index(SII),liver fibrosis level and poor prognosis in elderly patients with chronic and subacute liver failure.Methods A total of 105 elderly patients with chronic and subacute liver failure admitted to Shengjing Hospital Affilia-ted to China Medical University from March 2019 to June 2023 were selected as the study subjects.They were divided into good prognosis group(n=72)and poor prognosis group(n=33)according to their prognosis after treatment.The SIRI,SII and liver fibrosis factor 4 index(FIB-4)were compared between the two groups.Binary logistic regression analysis was used to screen the important risk factors for poor prognosis in elderly patients with chronic and subacute liver failure.Results The lev-els of alanine aminotransferase,aspartate aminotransferase,SIRI,SII and FIB-4 in the poor prognosis group were significantly higher than those in the good prognosis group,and the lymphocyte count was significantly lower than that in the good prognosis group(all P＜0.05).Univariate and multivariate Logistic regression analysis showed that high levels of SIRI,SII,and FIB-4 were important risk factors for elderly patients with chronic and subacute liver failure(P＜0.05).Conclusion SIRI,SII and FIB-4 can be used as potential biological markers to evaluate the prognosis of elderly patients with chronic and subacute liver failure,which provides a basis for further construction of prognostic risk prediction models.