不同药物干预方案在预防老年高血压性脑卒中后癫痫方面的回顾性研究

A retrospective study of different drug intervention regimens in prevention of epilepsy after hypertensive stroke in the elderly

中文关键词: 老年  脑卒中后癫痫  高血压  脑卒中  药物干预  回顾性研究

英文关键词: elderly  epilepsy after stroke  hypertension  cerebral apoplexy  drug intervention  retrospective study

中文摘要:

      目的 分析不同药物干预方案在预防老年高血压脑卒中后癫痫方面的效果差异.方法 选取2022年1月-2023年10月于淮北矿工总医院确诊为老年脑卒中后癫痫的80例患者纳入本研究,根据随访6个月结果,将他们分为高血压卒中后癫痫发作(PSE)组和非高血压PSE组,比较2组的一般资料及临床资料,统计并比较2组年龄、性别、脑卒中高危因素情况、他汀类药物服用情况、2组中服用他汀类药物患者的血清CRP水平的变化、NIHSS评分与PSE之间的关联;综合评价他汀类药物在预防老年高血压性PSE方面的效果.结果 80例脑卒中患者中,高血压PSE组患者共64例,非高血压PSE组共16例.2组患者的性别、年龄、吸烟史、饮酒史、糖尿病病史、冠心病病史差异均无统计学意义(P＞0.05);非高血压PSE组他汀类药物服用率明显低于高血压PSE组(31.23％vs 92.19％,P＜0.05);高血压PSE组中使用他汀类药物的患者CRP水平明显低于非高血压PSE组[(1.80±0.36)mg/L vs(3.22±0.26)mg/L,P＜0.05];高血压PSE组中轻度脑卒中患者占比明显高于非高血压PSE组(79.69％vs25.00％,P＜0.05);高血压PSE组中轻度脑卒中患者中服用他汀类药物者占比明显高于非高血压PSE组(92.16％vs 25.00％,P＜0.05).结论 服用他汀类药物可降低老年患者高血压性PSE风险,为防治高血压性PSE提供新思路,但仍需要通过大样本、多中心研究进一步加以论证.

英文摘要:

      Objective To analyze the effectiveness of different drug intervention regimens in the prevention of epilepsy after hypertensive stroke in the elderly.Methods A total of 80 elderly patients with post-stroke epilepsy treated in Huaibei Miners General Hospital from January 2022 to October 2023 were included in the study.According to the results of 6-month follow-up,they were divided into hypertensive post-stroke epilepsy(PSE)group and non-hypertensive PSE group.The general and clinical data of the two groups were compared.Age,gender,stroke risk factors,statin use,changes in serum CRP level of patients taking statins,and the correlation between NIHSS score and PSE were statistically compared between the two groups.The effect of statins in the prevention of hypertensive PSE in the elderly was comprehensively evaluated.Results Among 80 stroke patients;there were 64 ones in the hypertensive PSE group and 16 ones in the non-hypertensive PSE group.There was no significant difference in gender,age,smoking history,drinking history,diabetes history and coronary heart disease history be-tween the two groups(P＞0.05).The statin use rate in the non-hypertensive PSE group was significantly lower than that in the hypertensive PSE group(31.23％vs 92.19％,P＜0.05).The CRP level of patients using statins in the hypertensive PSE group was significantly lower than that in the non-hypertensive PSE group[(1.80±0.36)mg/L vs(3.22±0.26)mg/L,P＜0.05].The proportion of mild stroke patients in the hypertensive PSE group was significantly higher than that in the non-hypertensive PSE group(79.69％vs 25.00％,P＜0.05).The proportion of patients with mild stroke taking statins in the hy-pertensive PSE group was significantly higher than that in the non-hypertensive PSE group(92.16％vs 25.00％,P＜0.05).Conclusion Statins can reduce the risk of hypertensive PSE in elderly patients.It provides a new idea for prevention and treat-ment of hypertensive PSE,but it still needs to be further demonstrated by large sample and multi-center research.