老年晚期非小细胞肺癌患者化疗疗效的影响因素分析

Analysis of influencing factors of chemotherapy efficacy in elderly patients with advanced non-small cell lung cancer

中文关键词: 老年  非小细胞肺癌  晚期  化疗  临床疗效  影响因素

英文关键词: elderly  non-small cell lung cancer  advanced stage  chemotherapy  clinical efficacy  influencing factor

中文摘要:

      目的 分析影响老年晚期非小细胞肺癌(NCSLC)患者化疗效果的相关因素,为临床诊疗提供依据.方法 回顾性选取2023年3月-2024年3月在南通市肿瘤医院接受化疗治疗的老年晚期NSCLC患者99例,记录患者的性别、年龄、吸烟史、化疗方案、ALK突变、EGFR突变、饮酒史、肿瘤形态、肿瘤分化程度、TNM分期、化疗周期、ECOG评分、病理类型、营养诊断和脑转移情况.采用单因素和多因素Logistic回归方法,分析影响老年晚期NSCLC患者的化疗效果的相关因素.结果 化疗有效组和无效组患者性别构成、饮酒史、肿瘤形态、TNM分期、肿瘤分化程度、病理类型、化疗方案、化疗周期、ECOG评分差异均无统计学意义(均P＞0.05).化疗有效组和无效组患者在年龄、吸烟史、EGFR突变、ALK突变、营养诊断和脑转移差异均有统计学意义(均P＜0.05).年龄≥75、有吸烟史、中重度营养不良、发生脑转移为影响老年晚期NSCLC患者化疗效果的相关因素(P＜0.05).结论 化疗对老年晚期NSCLC患者具有一定疗效,但年龄≥75、有吸烟史、较低的化疗周期、中重度营养不良、及脑转移可能是影响老年晚期NSCLC患者化疗效果的相关因素,临床应采取有针对性的干预措施,以提高患者的临床疗效和预后.

英文摘要:

      Objective To analyze the related factors affecting chemotherapy efficacy in elderly patients with advanced non-small cell lung cancer(NCSLC),and provide evidence for clinical diagnosis and treatment.Methods 99 elderly patients with advanced NSCLC who received chemotherapy in Tumor Hospital of Nantong City from March 2023 to March 2024 were retrospectively selected.Their gender,age,smoking history,chemotherapy regimen,ALK mutation,EGFR mutation,alcohol consumption history,tumor morphology,tumor differentiation,TNM stage,chemotherapy cycle,ECOG score,pathological type,nutritional diagnosis and brain metastases were recorded.Univariate and multivariate logistic regression analysis were con-ducted to analyze the related factors affecting chemotherapy efficacy in elderly patients with advanced NSCLC.Results There were no significant differences in gender,drinking history,tumor morphology,TNM stage,tumor differentiation degree,path-ological type,chemotherapy regimen,chemotherapy cycle and ECOG score between the effective chemotherapy group and the ineffective chemotherapy group(all P＞0.05).There were significant differences in age,smoking history,EGFR mutation,ALK mutation,nutritional diagnosis and brain metastasis between the two groups(all P＜0.05).Age ≥75,smoking history,moderate to severe malnutrition and brain metastases were the related factors affecting chemotherapy efficacy in elderly patients with advanced NSCLC(P＜0.05).Conclusion Chemotherapy has a certain effect on elderly patients with advanced NSCLC,but age ≥75,smoking history,low chemotherapy cycle,moderate to severe malnutrition,and brain metastases are re-lated factors affecting chemotherapy efficacy in elderly patients with advanced NSCLC.Targeted intervention measures should be taken in clinical practice to improve the clinical efficacy and prognosis of patients.