我国中老年人肌少症患病现状及其影响因素分析⁃⁃基于ＣＨＡＲＬＳ数据库的 研究

Analysis of prevalence and influencing factors of sarcopenia in middle-aged and elderly people in China: A research based on CHARLS database

中文关键词: 中老年人  肌少症可能  患病率  影响因素

英文关键词: middle-aged and elderly  possible sarcopenia  prevalence  influence factor

中文摘要:

      目的　探讨我国中老年人肌少症的患病情况及其相关影响因素。 方法　使用中国健康与养老追踪调查（ＣＨＡＲＬＳ）的数据，分析我国中老年人群肌少症可能的患病率，分析比较了正常人和肌少症可能人群的基本资料及合并慢性病情况。 并将性别、年龄、ＢＭＩ、血压、脉搏、血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、ＣＲＰ、合并症、是否独居纳入Ｌｏｇｉｓｔｉｃ多因素回归分析发现肌少症可能人群的影响因素。 结果　最终纳入分析的有８０７２例调查者，根据握力及５次起坐时间筛选出肌少症可能的人群，发现我国中老年人群中肌少症可能的患病率达２４．８％，比较正常组和肌少症可能组的一般资料，发现肌少症可能组年龄、收缩压、脉搏、血糖、糖化血红蛋白、ＣＲＰ、独居比例、乡村居住比例高于正常组，ＢＭＩ、舒张压、三酰甘油低于正常组，并且差异具有统计学意义（Ｐ＜０.０５）。将性别、年龄、ＢＭＩ、血压、脉搏、血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、ＣＲＰ、合并症、是否独居纳入Ｌｏｇｉｓｔｉｃ多因素回归分析后发现性别［ＯＲ：１．３６５（１．２１８～１．５３０）］、年龄［ＯＲ：１．０８０ （１．０７４～１.０８６）］、 ＣＲＰ ［ＯＲ：１．０１５ （１．００９～ １.０２４）］、心脏病［ＯＲ：１．２２４ （１．０４３～１．４３５）］、中风［ＯＲ：１．７３２ （１．２５１～２.３９９）］、慢性肺部疾病［ＯＲ： １．１８８ （１．００７～ １．４０２）］、与记忆相关的疾病［ＯＲ：１．６３０ （１．０７０～２．４８３）］、关节炎或风湿病［ＯＲ： １．２４５ （１．１１０～１．３９６）］及独居［ＯＲ： １． ３１９ （１．１４７～１．５１７）］是其危险因素，而 ＢＭＩ ［ＯＲ： ０．９７６ （０．９６２～０．９９１）］、高密度脂蛋白［ＯＲ： ０．９９２ （０．９８７～ ０.９９７）］是其保护因素。 结论　我国中老年人群中肌少症可能的患病率达２４．８％，性别、年龄、 ＣＲＰ、心脏病、中风、慢性肺部疾病、与记忆相关的疾病、关节炎或风湿病及独居是其危险因素，而ＢＭＩ及高密度脂蛋白是其保护因素。

英文摘要:

      Objective To explore the prevalence and influence factors of sarcopenia in Chinese middle-aged and elderly people. Methods Based on the data from the China Health and Retirement Longitudinal Study ( CHARLS), the possible prevalence of sarcopenia in the middle-aged and elderly population in China was analyzed. The basic information and co-existing chronic diseases were analyzed and compared between the normal group and possible sarcopenia group. Gender, age, BMI blood pressure, pulse, blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, low-density lipoprotein, high density lipoprotein, CRP, comorbidities and living alone were included in the logistic multivariate regression analysis to determine the influence factors of sarcopenia. Results A total of 8072 investigators were included in the final analysis. The possible patients with sarcopenia were screened out according to grip strength and the time of 5 times of standing and sitting. It was found that the possible prevalence of sarcopenia was 24.8% in the middle-aged and elderly population in China. The age, systolic blood pressure, pulse, blood glucose, glycosylated hemoglobin, CRP, proportion of living alone and proportion of rural living in the possible sarcopenia group were higher than those in the normal group, while Bil, diastolic blood pressure and triacylglycerol were lower than those in the normal group. The differences were statistically significant ( P <0.05 ). After gender age, BMI, blood pressure, pulse, blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, CRP, comorbidity, and living alone were included in the logistic multivariate regression analysis.it was found that gender OR: 1.365 (1.218~1.530)], age OR:1.080(1.074~1.086)], CRP [OR: 1.015 (1.009~1.024)], heart disease [OR: 1.224(1.043~1.435), stroke [OR: 1.732 (1.251~2.399)], chronic lung disease [ OR.1.188 (1.007~1.402)], memory-related diseases [OR: 1.630(1.070~2.483 )], arthritis or rheumatism [OR: 1. 245(1.110~1.396)] and living alone[OR; 1.319 (1.147~1.517)] were risk factors for sarcopenia, while BMI OR: 0.976(0.962~0.991 )] and high-density lipoprotein [OR: 0.992 (0.987 ~0.997)] were protective factors. Conclusion The prevalence of possible sarcopenia in middle-aged and elderly people in China was 24.8%. Gender, age, CRP, heart disease stroke, chronic lung diseases, memory-related disease, arthritis or rheumatism and living alone are risk factors for sarcopenia, while BMI and high-density lipoprotein are protective factors.