新活素联合曲美他嗪治疗冠心病伴心功能不全老年患者的疗效分析

Analysis of curative effects of rhBNP combined with trimetazidine on elderly patients with coronary heart disease and cardiac insufficiency

中文关键词: 老年, 冠心病, 心功能不全, 曲美他嗪, 新活素, 炎症

英文关键词: elderly  coronary heart disease  cardiac insufficiency  trimetazidine  recombinant human brain natriuretic peptide  inflammation

中文摘要:

      目的 观察新活素联合曲美他嗪治疗冠心病(CHD)伴心功能不全(CI)老年患者的疗效.方法 选择成都市第三人民医院心内科2021年9月-2023年3月收治的112例CHD伴CI老年患者,按随机数字表法分成观察组(n=56)和对照组(n=56).对照组予以曲美他嗪治疗,观察组采用新活素联合曲美他嗪治疗,2组均连续治疗6个月.比较2组疗效、炎症应激指标值、心肌酶谱及用药安全性的差异.结果 治疗后,观察组治疗总有效率高于对照组(92.86％vs 78.57％,P＜0.05);2组丙二醛(MDA)、高敏C反应蛋白(hs-CRP)、单核细胞趋化因子-1(MCP-1)、肌钙蛋白I(c Tn I)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)水平均低于同组治疗前(P＜0.05),观察组上述指标值降低幅度大于对照组(P＜0.05);2组不良反应发生率差异无统计学意义(P＞0.05).结论 新活素与曲美他嗪联合治疗CHD伴CI老年患者的疗效确切,可有效改善炎症应激,促进心功能恢复,且安全性高.

英文摘要:

      Objective To explore the curative effects of lyophilized recombinant human brain natriuretic peptide(rh-BNP)combined with trimetazidine on elderly patients with coronary heart disease(CHD)and cardiac insufficiency(CI).Methods 112 elderly patients with CHD and CI admitted to Department of Cardiology of Third People's Hospital of Chengdu City from September 2021 to March 2023 were selected and divided into observation group(n=56)and control group(n=56)according to random number table method.The control group was treated with trimetazidine,and the observation group was treated with rh-BNP combined with trimetazidine.Both groups were treated for 6 months.The curative effect,inflammatory stress indexes,myocardial enzymes and medication safety were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group(92.86％vs 78.57％,P＜0.05).The levels of malondialdehyde(MDA),high-sensitivity C-reactive protein(hs-CRP),monocyte chemotactic protein-1(MCP-1),cardiac troponin I(cTnI),creatine kinase(CK)and creatine kinase isoenzyme(CK-MB)in both groups were lower than those in the same group before treatment,and the decrease in the above indicators in the observation group was greater than that in the con-trol group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of rh-BNP and trimetazidine has a definite curative effect on elderly patients with CHD and CI.It can effectively reduce inflammatory stress,promote cardiac function recovery,and has high safety.