纤维支气管镜支气管肺泡灌洗联合甲强龙治疗对老年支气管扩张合并感染患者血气分析、炎症因子及肺功能的影响

Effects of fiberoptic bronchoscopic BAL combined with methylprednisolone on blood gas analysis,inflammatory factors and lung function in elderly patients with bronchiectasis complicated with infection

中文关键词: 老年, 支气管扩张, 纤维支气管镜, 支气管肺泡灌洗, 甲强龙, 血气分析, 肺功能

英文关键词: elderly  bronchiectasis  fiberoptic bronchoscope  bronchoalveolar lavage  methylprednisolone  blood gas analysis  lung function

中文摘要:

      目的 观察纤维支气管镜支气管肺泡灌洗(BAL)与甲强龙联合治疗对老年支气管扩张合并感染患者血气分析、炎症因子及肺功能的影响.方法 回顾性分析2021年1月-2024年1月宜宾市第三人民医院收治的102例老年支气管扩张合并感染患者的病例资料,根据不同治疗的方式将患者分为联合组(纤维支气管镜BAL联合甲强龙,n=52)和对照组(纤维支气管镜BAL,n=50).观察并比较2组疗效、血气指标值、炎症因子水平、肺功能.结果 与对照组相比,联合组临床疗效总有效率更高(P＜0.05).与同组治疗前相比,2组治疗后PaO2、SaO2、FVC、FEV1、FEV1/FVC水平均上升(P＜0.05),联合组比对照组更高(P＜0.05);2组患者治疗后PaCO2、CRP、PCT、ESR水平降低(P＜0.05),联合组比对照组更低(P＜0.05).结论 纤维支气管镜BAL联合甲强龙治疗老年支气管扩张合并感染患者,效果显著,可促进患者肺功能恢复,改善氧合能力,缓解机体炎症反应.

英文摘要:

      Objective To observe the effects of fiberoptic bronchoscopic bronchoalveolar lavage(BAL)combined with methylprednisolone on blood gas analysis,inflammatory factors and lung function in elderly patients with bronchiectasis compli-cated with infection.Methods The case of 102 elderly patients with bronchiectasis combined with infection admitted to Third People's Hospital of Yibin City from January 2021 to January 2024 were retrospectively analyzed.They were divided into com-bined group(fiberoptic bronchoscopic BAL combined with methylprednisolone,n=52)and control group(fiberoptic broncho-scopic BAL,n=50)according to different treatment methods.The therapeutic effect,blood gas index values,inflammatory factor level and lung function of the two groups were observed and compared.Results The total effective rate of clinical effi-cacy in the combined group was higher than that in the control group(P＜0.05).After treatment,the levels of PaO2,SaO2,FVC,FEV,and FEV1/FVC in both groups were higher than those in the same group before treatment(P＜0.05),and the lev-els in the combined group were higher than those in the control group(P＜0.05);the levels of PaCO2,CRP,PCT and ESR in both groups were lower than those in the same group before treatment(P＜0.05),and the levels in the combined group were lower than those in the control group(P＜0.05).Conclusion The combination of fiberoptic bronchoscopy BAL and methyl-prednisolone is effective in the treatment of elderly patients with bronchiectasis complicated with infection,which can promote the recovery of lung function,improve the oxygenation capacity and alleviate the inflammatory response of the body.