麦粒灸结合针刺治疗老年急性期带状疱疹患者疗效及对血清IL-17、IL-8、SP的影响

Therapeutic effects of wheat grain moxibustion combined with acupuncture on elderly patients with acute herpes zoster and its effects on serum IL-17,IL-8 and SP

中文关键词: 老年, 急性期带状疱疹, 麦粒灸, 针刺治疗, 白介素-17, 白介素-8, 血清P物质

英文关键词: elderly  acute herpes zoster  wheat grain moxibustion  acupuncture  interleukin-17  interleukin-8  serum substance P

中文摘要:

      目的 观察麦粒灸结合针刺治疗老年急性期带状疱疹疗效及对血清白介素-17(IL-17)、白介素-8(IL-8)、血清P物质(SP)的影响.方法 将2022年1月-2024年1月成都中医药大学附属医院收治的118例老年急性期带状疱疹患者纳入研究,使用随机信封法将患者分为联合组与针刺组,2组59例.针刺组接受常规药物治疗+针刺治疗,联合组在针刺组治疗基础上联合麦粒灸治疗,2组均连续治疗1周.对比2组治疗有效率、中医证候积分、疼痛程度[采用模拟视觉评分量表(VAS)评估]、免疫功能(CD4+、CD8+、CD4+/CD8+)、血清IL-17、IL-8、SP水平、后遗神经痛和不良反应发生率.结果 治疗后,联合组治疗有效率为高于针灸组的(96.61％vs 84.75％,P＜0.05);联合组中医证候积分均低于针刺组(P＜0.05);2组VAS评分于组间、时间点及交互差异均有统计学意义(P＜0.05),联合组各时间点VAS评分均低于针刺组(P＜0.05);联合组CD4+、CD4+/CD8+值高于针刺组(P＜0.05),CD8+值低于针刺组(P＜0.05);联合组血清IL-17、IL-8、SP水平均低于针刺组(P＜0.05);联合组后遗神经痛发生率低于针刺组(P＜0.05);2组患者治疗不良反应差异无统计学意义(P＞0.05).结论 麦粒灸结合针刺可有效提高老年急性期带状疱疹患者的临床疗效,改善其症状表现,缓解疼痛,提高免疫力,降低炎症反应和后遗神经痛发生率,具有一定的临床应用价值.

英文摘要:

      Objective To observe the therapeutic effects of wheat grain moxibustion combined with acupuncture on eld-erly patients with acute herpes zoster and its effects on serum interleukin-17(IL-17),interleukin-8(IL-8)and substance P(SP).Methods 118 elderly patients with acute herpes zoster admitted to Affiliated Hospital of Chengdu University of Tradi-tional Chinese Medicine(TCM)from January 2022 to January 2024 were included in this study.According to random envelope method,they were divided into acupuncture group and combination group,with 59 cases in each group.The acupuncture group received conventional drug treatment plus acupuncture treatment,and the combination group received wheat grain moxibustion on the basis of the acupuncture group.Both groups received continuous treatment for one week.The treatment effective rate,TCM syndrome score,pain degree[Visual Analogue Scale(VAS)],immune function(CD4+,CD8+,CD4+/CD8+),lev-els of serum IL-17,IL-8 and SP,and the incidences of postherpetic neuralgia and adverse reactions were compared between the two groups.Results After treatment,the effective rate of the combination group was higher than that of the acupuncture group(96.61％vs 84.75％,P＜0.05)and the TCM syndrome score was lower than that of the acupuncture group(P＜0.05).There were significant differences in VAS scores in terms of inter-group dimension,time point dimension and interaction dimen-sion(P＜0.05),and VAS scores of the combination group were significantly lower than those of the acupuncture group at dif-ferent time points(P＜0.05).The levels of CD4+and CD4+/CD8+of the combination group were higher than those of the ac-upuncture group,while CD8+was lower than that of the acupuncture group(P＜0.05).The levels of IL-17,IL-8 and SP of the combination group were lower than those of the acupuncture group(P＜0.05).The incidence of postherpetic neuralgia in the combination group was lower than that in the acupuncture group(P＜0.05).There was no significant difference in the in-cidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of wheat grain moxibustion and acupuncture can effectively improve the clinical curative effect of elderly patients with acute herpes zoster,improve their symptoms,relieve pain,enhance immunity,and reduce inflammatory response and the incidence of postherpetic neuralgia.It has certain clinical application value.