丹参酮联合普瑞巴林胶囊治疗老年带状疱疹后遗神经痛的临床研究

A clinical study on combination of tanshinone and pregabalin capsule in treatment of postherpetic neuralgia in elderly patients

中文关键词: 老年, 带状疱疹后遗神经痛, 丹参酮, 普瑞巴林胶囊, 临床疗效

英文关键词: elderly  postherpetic neuralgia  tanshinone  pregabalin capsule  clinical efficacy

中文摘要:

      目的 观察丹参酮联合普瑞巴林胶囊治疗老年带状疱疹后遗神经痛的临床疗效.方法 采集2022年12月-2024年1月在海门区人民医院皮肤科门诊接受治疗的96例老年带状疱疹后遗神经痛患者作为研究对象,通过数字表法随机分为观察组和对照组,每组48例.对照组接受甲钴胺片口服治疗,每次1片,每天3次;普瑞巴林胶囊口服,每次1粒,每日2次;观察组在对照组治疗的基础上,加用口服丹参酮胶囊,每次4粒,每日3次.2组患者都接受了为期4周的治疗.分别对比2组在治疗前后的视觉模拟评分法(VAS)评分、匹兹堡睡眠质量指数(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分及临床疗效.结果 治疗后,2组患者VAS、PSQI、HAMA评分均显著下降,且观察组患者评分均明显低于对照组,差异均有统计学意义(P＜0.05);观察组总有效率显著高于对照组(91％vs 75％,P＜0.05).结论 临床应用丹参酮胶囊联合普瑞巴林胶囊疗效可靠,又具有中西医结合的优势互补,且中药内服对老年人更加安全,具有一定的临床推广价值.

英文摘要:

      Objective To observe the clinical effects of tanshinone combined with pregabalin capsule on postherpetic neuralgia in elderly patients.Methods 96 elderly patients with postherpetic neuralgia who received treatment in Dermatology Clinic of People's Hospital of Haimen District from December 2022 to January 2024 were collected as research subjects.They were randomly divided into observation group and control group by digital table method,with 48 cases in each group.The con-trol group received mecobalamine tablet orally,1 tablet each time,3 times a day;pregabalin capsule,taken orally,1 capsule each time,twice a day.On the basis of treatment in the control group,the observation group was given oral tanshinone cap-sule,4 capsules each time,3 times a day.Both groups received treatment for 4 weeks.The visual analog scale(VAS)scores,Pittsburgh Sleep Quality Index(PSQI)scores,Hamilton Anxiety Scale(HAMA)scores and clinical efficacy of the two groups were compared before and after treatment.Results After treatment,the scores of VAS,PSQI and HAMA of the two groups decreased significantly,and the scores of the observation group were significantly lower than those of the control group(P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group(91％vs 75％,P＜0.05).Conclusion The clinical application of tanshinone capsule combined with pregabalin capsule has reliable therapeu-tic effects and complementary advantages of integration of traditional Chinese and Western medicine.Moreover,oral adminis-tration of traditional Chinese medicine is safe for the elderly.Therefore,it has certain clinical promotion value.