D2聚体/纤维蛋白原、血清C反应蛋白/前白蛋白比值、红细胞分布宽度与老年AECOPD疾病严重程度的相关性分析

Correlation analysis of D2/FIB,CRP/PAB and RDW and severity of AECOPD in elderly patients

中文关键词: 老年  慢性阻塞性肺疾病急性加重期  疾病严重程度  D2聚体/纤维蛋白原比值  C反应蛋白/前白蛋白比值  红细胞分布宽度

英文关键词: elderly  acute exacerbation of chronic obstructive pulmonary disease  severity of disease  D2 polymer/fibrinogen ratio  C-reactive protein/prealbumin ratio  red blood cell width

中文摘要:

      目的 分析D2聚体(D2)/纤维蛋白原(FIB)比值(D2/FIB)、C反应蛋白(CRP)/前白蛋白(PAB)比值(CRP/PAB)、红细胞分布宽度(RDW)与老年慢性阻塞性肺疾病急性加重期(AECOPD)患者疾病严重程度的相关性.方法 选择2023年1月—2024年10月在合肥市第三人民医院收治的128例老年AECOPD患者为研究组,另同期选择48名体检健康老年人为对照组;根据研究组病情分为轻度加重亚组(42例)、中度加重亚组(55例)和重度加重亚组(31例).对比不同亚组之间的D2/FIB和CRP/PAB及RDW表达,分析各指标值与病情严重程度的相关性,最后评价诊断效能.结果 与对照组相比,研究组D2/FIB和CRP/PAB及RDW值升高(P＜0.05);与轻度加重亚组相比,中、重度加重亚组D2/FIB和CRP/PAB及RDW值升高(P＜0.05);与中度加重亚组相比,重度加重亚组D2/FIB和CRP/PAB及RDW值升高(P＜0.05).相关性显示,D2/FIB和CRP/PAB值升高与其病情严重程度呈正相关.D2/FIB、CRP/PAB及RDW值预测病情加重的AUC值分别为0.689、0.738和0.752,而三者联合检测的AUC为0.851,高于各指标单独检测(P＜0.05).结论 老年AECOPD患者D2/FIB、CRP/PAB及RDW值升高与其病情严重程度可能具有较高的相关性,且三者联合检测的诊断效能优于单独指标检测.

英文摘要:

      Objective To analyze the correlations of D2 polymers(D2)/fibrinogen(FIB)ratio(D2/FIB),C-reac-tive protein(CRP)/prealbumin(PAB)ratio(CRP/PAB)and red blood cell distribution width(RDW)with disease severity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 128 elderly pa-tients with AECOPD admitted to Third People's Hospital of Hefei City from January 2023 to October 2024 were selected as study group,and 48 healthy elderly individuals who underwent physical examinations were selected as control group during the same period.The patients in the study group was further divided into mild exacerbation(n=42),moderate exacerbation(n=55)and severe exacerbation(n=31)subgroups.The levels of D2/FIB,CRP/PAB and RDW were compared among the three subgroups.Correlations between these indexes and disease severity were analyzed,and diagnostic performance was evaluated.Results Compared with the control group,the levels of D2/FIB,CRP/PAB and RDW in the study group increased signifi-cantly(P＜0.05).Compared with the mild subgroup,the levels of D2/FIB,CRP/PAB and RDW in the moderate exacerba-tion and severe exacerbation subgroups increased significantly(P＜0.05).Compared with the moderate subgroup,the levels of D2/FIB,CRP/PAB and RDW in the severe exacerbation subgroup increased significantly(P＜0.05).Correlation showed that elevated D2/FIB and CRP/PAB values were positively correlated with the severity of the disease.The AUC values of D2/FIB,CRP/PAB and RDW for predicting exacerbation severity of disease were 0.689,0.738,and 0.752,respectively.The AUC of the combined detection of the three indicators was 0.851,which was higher than that of the individual detection of each index(P＜0.05).Conclusion Elevated D2/FIB,CRP/PAB and RDW levels are strongly associated with disease severity in elder-ly AECOPD patients,and the diagnostic efficiency of the combined detection of the three indexes is better than that of the indi-vidual detection of each index.