基于亚洲肌少症共识2014和2019标准的中国老年2型糖尿病患者肌少症患病率及相关因素的差异分析

Difference analysis of prevalence of sarcopenia and related factors in elderly Chinese patients with type 2 diabetes based on cri-teria of 2014 and 2019 Asian Consensus on Sarcopenia

中文关键词: 老年  肌少症  患病率  2型糖尿病

英文关键词: elderly  sarcopenia  prevalence  type 2 diabetes mellitus

中文摘要:

      目的 依据亚洲肌少症工作组(Asian Working Group for Sarcopenia,AWGS)2014 年(AWGS2014)和 2019 年(AWGS2019)的诊断标准,对比分析中国老年2型糖尿病(T2DM)患者中肌少症的患病率及相关因素的差异.方法 选取2016年2月—2017年1月在上海市第十人民医院住院治疗的116例老年T2DM患者作为研究对象.通过采集血液样本、测量握力、步速和四肢骨骼肌质量,并根据AWGS2014和AWGS2019的标准诊断肌少症;采用SPSS 28.0统计软件分析2种标准下肌少症患病率的差异,并通过二元逻辑回归分析评估肌少症的相关因素.结果 依据AWGS2014和AWGS2019的标准,中国老年T2DM患者肌少症的患病率分别为36.2％和56.0％;且年龄和BMI均与肌少症相关.在AWGS2014的诊断标准中,血清白蛋白(Alb)水平是肌少症的保护性因素,但其在AWGS2019的标准中未得到验证.相较于AWGS2014的诊断标准,采用AWGS2019的诊断标准评估的中国老年2型糖尿病患者中肌少症的患病率更高,且年龄增长和BMI降低均为一致的风险因素;但血清白蛋白水平仅在AWGS2014的标准中与肌少症相关.结论 肌少症的诊断标准会影响患病率及相关因素的识别,需要进一步的研究来确认哪些临床指标对肌少症更为敏感,以推动肌少症的早期临床诊断和干预.

英文摘要:

      Objective To compare and analyze the prevalence and related factors of sarcopenia in elderly Chinese pa-tients with type 2 diabetes mellitus(T2DM)based on the diagnostic criteria of the Asian Working Group for Sarcopenia(AWGS)in 2014(AWGS2014)and 2019(AWGS2019).Methods 116 elderly T2DM patients aged 60 and above from Shanghai Tenth People's Hospital between February 2016 and January 2017 were selected.Their blood samples were collected,and grip strength,gait speed and skeletal muscle mass of the limbs were measured.Sarcopenia was diagnosed according to the AWGS2014 and AWGS2019 criteria,respectively.SPSS 28.0 software was used to analyze and compare the difference in the prevalence of sarcopenia between the two criteria.The related factors of sarcopenia were identified by binary Logistic regression analysis.Results According to the AWGS2014 and AWGS2019 criteria,the prevalence of sarcopenia in elderly Chinese T2DM patients was 36.2％and 56.0％,respectively.Age and BMI were associated with sarcopenia under both criteria.Under the AWGS2014 criteria,serum albumin(Alb)level was identified as a protective factor for sarcopenia,but this finding was not verified under the AWGS2019 criteria.Compared with AWGS2014,the AWGS2019 criteria yielded a higher prevalence of sarcopenia in elderly Chinese T2DM patients.Increased age and decreased BMI were consistent risk factors for sarcopenia,while serum Alb level was only significantly associated with sarcopenia under the AWGS2014 criteria.Conclusion The diag-nostic criteria for sarcopenia influence both its prevalence and the identification of related factors.Further research is needed to determine which clinical indicators are more sensitive for sarcopenia diagnosis,thereby facilitating early clinical diagnosis and intervention for sarcopenia.