老年男性2型糖尿病患者合并肌少-骨质疏松症相关因素研究

A study on related factors of osteosarcopenia in elderly male patients with type 2 diabetes mellitus

中文关键词: 老年  男性  2型糖尿病  肌少-骨质疏松症

英文关键词: elderly  male  type 2 diabetes mellitus  osteosarcopenia

中文摘要:

      目的 探讨老年男性2型糖尿病(T2DM)患者合并肌少-骨质疏松症(OS)的可能危险因素.方法 选取2022年1月—2024年5月北京医院体检的60岁及以上老年男性T2DM患者404例.采集受试者基线信息;评估优势手握力、5次起坐时间和6 m步速;双能X射线吸收法测定骨密度及身体成分.单因素和多因素Logistic回归法分析老年男性T2DM合并OS的影响因素.结果 老年男性T2DM患者OS患病率28.96％(117/404).多因素Logistic回归分析显示,体质量指数(OR=0.902,95％CI:0.775～0.986)、腰椎最低骨密度(OR=0.000,95％CI:0.000～0.014)及股骨颈骨密度(OR=0.001,95％CI:0.000～0.022)升高为 OS 的保护因素;增龄(OR=1.133,95％CI;1.052～1.257)、体脂率(OR=1.171,95％CI:1.008～1.421)升高及罹患慢性阻塞性肺疾病(OR=1.026,95％CI;1.007～1.052)为 OS 的危险因素.结论 老年男性T2DM患者OS患病率较高,应关注体脂率较高、体质量指数与骨密度较低的高危人群.

英文摘要:

      Objective To explore potential risk factors for osteosarcopenia(OS)in elderly male patients with type 2 di-abetes mellitus(T2DM).Methods A total of 404 elderly male T2DM patients aged 60 and above who underwent physical examinations in Beijing Hospital from January 2022 to May 2024 were selected.Their baseline information was collected.The dominant hand grip strength,5-time sit-to-stand test,and 6-meter gait speed were measured.Dual-energy X-ray absorptiometry(DXA)was used to determine bone mineral density(BMD)and body composition.Univariate and multivariate Logistic re-gression analyses were performed to identify influencing factors for OS in elderly male T2DM patients.Results The preva-lence of OS among elderly male T2DM patients was 28.96％(117/404).Multivariate Logistic regression analysis showed that higher body mass index(OR=0.902,95％CI:0.775-0.986),increased lowest lumbar bone mineral density(OR=0.000,95％CI:0.000-0.014),and elevated femoral neck bone mineral density(OR=0.001,95％CI;0.000-0.022)were protec-tive factors for OS,while advanced age(OR=1.133,95％CI:1.052-1.257),higher body fat percentage(OR=1.171,95％CI;1.008-1.421),and comorbid chronic obstructive pulmonary disease(OR=1.026,95％CI:1.007-1.052)were risk factors for OS.Conclusion The prevalence of OS is higher in elderly male T2DM patients,and attention should be paid to high-risk populations with higher body fat percentage,lower body mass index,and lower bone mineral density.