SII联合TNF-α、IL-6水平评估老年慢性阻塞性肺疾病急性加重患者疾病严重程度及预后的价值

Value of SII combined with TNF-α and IL-6 levels in evaluating severity and prognosis of acute exacerbation of COPD in elderly patients

中文关键词: 老年  慢性阻塞性肺疾病  全身免疫炎症指数  肿瘤坏死因子-α  白介素-6  疾病严重程度  预后

英文关键词: lderly  chronic obstructive pulmonary disease  systemic immune inflammatory index  tumor necrosis factor-α  interleukin-6  severity of disease  prognosis

中文摘要:

      目的 探究全身免疫炎症指数(SII)联合肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平评估老年慢性阻塞性肺疾病急性加重(AECOPD)患者疾病严重程度及预后的价值.方法 回顾性分析2024年1月-2024年8月亳州市中医院收治的95例老年AECOPD患者的临床资料,按照疾病严重程度分为Ⅰ级组(n=14)、Ⅱ级组(n=35)、Ⅲ级组(n=29)、Ⅳ级组(n=17),根据随访结果将患者分为预后良好组(n=64)与预后不良组(n=31).比较不同疾病严重程度及预后患者的SII、TNF-α、IL-6水平;采用Spearman相关性分析探究SII、TNF-α、IL-6水平与预后的关系,绘制受试者工作特征(ROC)曲线分析上述指标及联合对于患者不良预后的预测效能.结果 不同疾病严重程度及预后的老年AECO-PD患者SII、TNF-α、IL-6水平差异有统计学意义(P＜0.05).Spearman相关性分析结果显示,患者不良预后与SII、TNF-α、IL-6呈正相关(P＜0.05).ROC曲线分析结果显示,SII、TNF-α、IL-6预测AECOPD患者预后的曲线下面积(AUC)值分别为0.641、0.668、0.635,联合后的AUC值为0.717.结论 不同疾病严重程度的老年AECOPD患者SII、TNF-α、IL-6水平存在差异,SII、TNF-α、IL-6与患者预后存在密切关联,SII联合TNF-α、IL-6对于预测老年AECOPD患者预后可能具有较好的效能.

英文摘要:

      Objective To explore the value of systemic immune inflammatory index(SII)combined with tumor necro-sis factor alpha(TNF-α)and interleukin-6(IL-6)levels in evaluating the severity and prognosis of acute exacerbation of chro-nic obstructive pulmonary disease(AECOPD)in elderly patients.Methods A retrospective analysis was conducted on the clinical data of 95 elderly patients with AECOPD admitted to Hospital of Traditional Chinese Medicine of Bozhou City from January to August 2024.They were divided into grade Ⅰ group(n=14),grade Ⅱ group(n=35),grade Ⅲ group(n=29),and grade Ⅳ group(n=17)based on disease severity.In addition,they were divided into good prognosis group(n=64)and poor prognosis group(n=31)based on follow-up results.The levels of SII,TNF-α and IL-6 in patients with different severi-ties and different prognoses were compared.Spearman's correlation was used to analyze the correlation between the levels of SII,TNF-α and IL-6 and the prognosis.The receiver operating characteristic(ROC)curve was plotted to analyze the predic-tive efficacy of the above indicators and their combination for the poor prognosis of patients.Results Significant differences in the levels of SII,TNF-α and IL-6 were observed among different severity grades and prognostic groups(P＜0.05).Spearman's correlation analysis results showed that poor prognosis was positively correlated with SII,TNF-α,and IL-6(P＜0.05).ROC curve analysis results showed that the areas under the curve(AUCs)of SII,TNF-α and IL-6 for predicting the prognosis in eld-erly patients with AECOPD were 0.641,0.668,and 0.635,respectively.The AUC of their combined prediction was 0.717.Conclusion There are differences in the levels of SII,TNF-α and IL-6 among elderly AECOPD patients with different disease severity.SII,TNF-α and IL-6 are closely related to the prognosis of patients.The combination of SII and TNF-α and IL-6 may have a good efficacy in predicting the prognosis of elderly AECOPD patients.