升阳益胃汤加味治疗老年慢性萎缩性胃炎患者的临床疗效分析

Analysis of clinical efficacy of modified Shengyang Yiwei decoction in treatment of elderly patients with chronic atrophic gastritis

中文关键词: 老年  慢性萎缩性胃炎  脾胃虚弱  升阳益胃汤加味  胃肠激素  炎症指标

英文关键词: elderly  chronic atrophic gastritis  spleen-stomach deficiency type  modified Shengyang Yiwei decoction  gastrointestinal hormone  inflammatory index

中文摘要:

      目的 观察升阳益胃汤加味对老年脾胃虚弱型慢性萎缩性胃炎(CAG)患者的治疗作用及对胃肠激素、炎症指标的影响.方法 选取2022年8月-2023年7月于青岛市胶州中心医院中医门诊及消化内科门诊进行就诊的80例老年CAG(脾胃虚弱型)患者,按照随机数字表法分为对照组和观察组,每组40例.对照组采用常规西医治疗,观察组在对照组治疗的基础上加用升阳益胃汤加味,2组均连续治疗12周.对比治疗前和治疗12周后2组患者中医证候积分、血清胃肠激素[胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PG Ⅰ)、胃蛋白酶原Ⅱ(PG Ⅱ)]水平、血清炎症指标[肿瘤坏死因子α(TNF-α)、白介素-8(IL-8)、白介素-6(IL-6)]水平;评估并比较2组患者治疗效果、治疗期间不良反应发生情况.结果 治疗4周后,观察组治疗总有效率高于对照组(P＜0.05);治疗12周后,2组患者中医证候积分、血清炎症因子(TNF-α、IL-8、IL-6)水平均低于治疗前(P＜0.05),且观察组上述指标值低于对照组(P＜0.05);2组患者血清胃肠激素(G-17、PG-Ⅰ、PG-Ⅱ)水平均高于同组治疗前(P＜0.05),且观察组上述指标值高于对照组(P＜0.05);2组患者不良反应发生率差异无统计学意义(P＞0.05).结论 升阳益胃汤加味可改善老年CAG(脾胃虚弱型)患者的中医证候积分、临床效果,调节胃肠激素分泌,降低炎症反应,且安全性较高,具有一定的临床应用价值.

英文摘要:

      Objective To observe the therapeutic effects of modified Shengyang Yiwei decoction on elderly patients with chronic atrophic gastritis(CAG)(spleen-stomach deficiency type),and its influence on gastrointestinal hormones and in-flammatory indexes.Methods 80 elderly CAG patients(spleen-stomach deficiency type)treated in Outpatient Department of Traditional Chinese Medicine and Outpatient Department of Gastroenterology of Jiaozhou Central Hospital from August 2022 to July 2023 were selected and divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with modified Shengyang Yiwei decoction based on the control group.Both groups were consecutively treated for 12 weeks.Before treatment and after 12 weeks of treatment,the traditional Chinese medicine(TCM)syndromes scores,thera-peutic effect,levels of serum gastrointestinal hormones[gastrin-17(G-17),pepsinogen Ⅰ(PG-Ⅰ),pepsinogen Ⅱ(PG-Ⅱ)]and serum inflammatory indexes[tumor necrosis factor α(TNF-α),interleukin-8(IL-8),interleukin-6(IL-6)]were compared between the two groups.The adverse reactions of the two groups were recorded during treatment.Results After 4 weeks of treatment,the total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After 12 weeks of treatment,the scores of TCM syndromes and levels of serum inflammatory factors(TNF-α,IL-8,IL-6)in the two groups were lower than those in the same group before treatment,and the observation group was lower than the control group(P＜0.05).The levels of serum gastrointestinal hormones(G-17,PG-Ⅰ,PG-Ⅱ)in both groups were higher than those in the same group before treatment,and the observation group was higher than the control group(P＜0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Modi-fied Shengyang Yiwei decoction can significantly improve the TCM syndromes scores and clinical efficacy in elderly patients with CAG(spleen-stomach deficiency type),regulate the secretions of gastrointestinal hormones,and reduce the inflammatory response.It has high safety and certain clinical application value.