瑞舒伐他汀联合桃红四物汤对老年骨质疏松性椎体压缩性骨折患者的影响

Effects of rosuvastatin combined with Taohong Siwu decoction on elderly patients with osteoporotic vertebral compression fracture

中文关键词: 老年  骨质疏松性椎体压缩性骨折  瑞舒伐他汀  桃红四物汤  经皮锥体成形术  骨密度  血清标志物

英文关键词: elderly  osteoporotic vertebral compression fracture  rosuvastatin  Taohong Siwu decoction  percutaneous vertebroplasty  bone density  serum biomarker

中文摘要:

      目的 探究瑞舒伐他汀联合桃红四物汤对老年骨质疏松性椎体压缩性骨折患者术后疼痛程度及功能障碍的影响,为治疗该病症提供方法.方法 选择2021年12月-2024年12月在湖南中医药大学第二附属医院治疗的126例老年骨质疏松性椎体压缩性骨折患者,根据随机数字表法分为观察组和对照组,每组63例.2组患者均接受经皮锥体成形术(PVP)治疗,对照组在此基础上接受桃红四物汤治疗,观察组在与对照组相同治疗的基础上加用瑞舒伐他汀治疗.比较2组治疗前后的骨密度、骨特异性碱性磷酸酶(BAP)水平、Ⅰ型胶原羧基端肽(CTX)水平、视觉模拟量表(VAS)评分、Oswestry残疾指数(ODI)评分及骨相关血清标志物水平.结果 治疗后,2组患者骨密度均高于同组治疗前,观察组骨密度高于对照组,差异均有统计学意义(P＜0.05);2组患者BAP、CTX评分及ODI评分均低于同组治疗前,观察组BAP、CTX评分及ODI评分均低于对照组,差异均有统计学意义(P＜0.05);2组患者钙、磷、ALP水平均高于同组治疗前,观察组钙、磷、ALP水平均高于对照组,差异均有统计学意义(P＜0.05).结论 瑞舒伐他汀和桃红四物汤可联合治疗老年骨质疏松性椎体压缩性骨折患者,可改善患者功能状态及骨相关血清标志物水平,增加椎体骨密度,降低骨吸收活性,减轻疼痛,具有一定的临床应用价值.

英文摘要:

      Objective To investigate the effects of rosuvastatin combined with Taohong Siwu decoction on postoperative pain and functional impairment in elderly patients with osteoporotic vertebral compression fracture(OVCF),and provide thera-peutic strategies for this condition.Methods 126 elderly OVCF patients treated in Second Affiliated Hospital of Hunan Univer-sity of Chinese Medicine from December 2021 to December 2024 were selected and divided into observation group and control group according to the random number table method,with 63 cases in each group.Both groups received percutaneous vertebro-plasty(PVP)treatment.The control group was treated with Taohong Siwu decoction on this basis,while the observation group was treated with rosuvastatin in addition to the same treatment as the control group.Bone mineral density,the levels of bone-specific alkaline phosphatase(BAP),carboxyl-terminal peptide(CTX)of type Ⅰ collagen and bone-related serum markers,and the scores of Visual Analogue Scale(VAS)and Oswestry Disability Index(ODI)before and after treatment were com-pared between the two groups.Results After treatment,bone mineral density of both groups were higher than those of the same group before treatment,and the observation group was higher than the control group,with a statistical difference(P＜0.05);BAP level,CTX score and ODI score were lower than those of the same group before treatment,and the observation group was lower than the control group,with a statistical difference(P＜0.05);the levels of calcium,phosphorus and ALP of both groups were higher than those of the same group before treatment,and the observation group was higher than the control group,with a statistical difference(P＜0.05).Conclusion Rosuvastatin and Taohong Siwu decoction can be used in combina-tion to treat elderly OVCF patients.It can improve the functional status of patients and the levels of bone related serum markers,increase vertebral bone density,reduce bone resorption activity,alleviate pain,and has certain clinical application value.