老年类风湿性关节炎患者伴发脑卒中的现状及相关因素分析

Analysis of current situation and related factors for stroke in elderly patients with rheumatoid arthritis

中文关键词: 老年  类风湿性关节炎  脑卒中  危险因素  关节疾病活动性  血清学检测

英文关键词: elderly  rheumatoid arthritis  stroke  risk factor  activity of joint disease  serological detection

中文摘要:

      目的 探讨老年类风湿性关节炎(RA)患者伴发脑卒中的现状及相关因素.方法 回顾性选择2021年2月-2024年2月在重庆市南川区中医医院因RA相关症状就诊的180例老年RA患者作为研究对象,根据是否合并脑卒中将RA患者分为RA合并脑卒中组(n=41)和非脑卒中组(n=139).统计RA患者脑卒中发生率,采用单因素和多因素Logistic回归方法分析影响RA患者伴发脑卒中的危险因素.结果 180例患者中,脑卒中发生率为22.78％(41/180).2组患者在年龄、病程、28关节疾病活动性评分、同型半胱氨酸(Hcy)、C反应蛋白(CRP)、D-二聚体(D-D)差异有统计学意义(P＜0.05).多因素Logistic回归分析显示,Hcy、CRP、D-D水平是影响RA患者发生脑卒中的独立危险因素(P＜0.05).结论 老年RA患者发生脑卒中的风险较高,可能与Hcy、CRP、D-D等因素有关,提示临床需重视上述因素并给予干预,以降低脑卒中风险.

英文摘要:

      Objective To explore the current situation and related factors for stroke in elderly patients with rheumatoid arthritis(RA).Methods A retrospective study included 180 elderly RA patients who received treatment for RA related symp-toms in Hospital of Traditional Chinese Medicine of Nanchuan District,Chongqing from February 2021 to February 2024.Ac-cording to presence or absence of stroke,they were divided into stroke group(n=41)and non-stroke group(n=139).The incidence of stroke in RA patients was statistically analyzed,and risk factors for stroke were analyzed by univariate and multiva-riate Logistic regression analysis.Results Among the 180 patients,the incidence of stroke was 22.78％(41/180).There were significant differences in age,course of disease,score of Disease Activity Score-28(DAS28),homocysteine(Hcy),C-reactive protein(CRP)and D-dimer(D-D)between the two groups(P＜0.05).Multivariate Logistic regression analysis showed that Hcy,CRP and D-D were independent risk factors for stroke in RA patients(P＜0.05).Conclusion The risk of stroke is high in elderly patients with RA,which may be related to Hcy,CRP and D-D.Clinically,the above factors should to be payed attentions to and intervention should be taken to reduce the risk of stroke.