老年代谢相关脂肪性肝病及其纤维化程度与冠心病的相关性分析

Study on relationship between metabolic-associated fatty liver disease and its fibrosis degree with coronary artery disease in the elderly

中文关键词: 老年  代谢相关脂肪性肝病  冠状动脉粥样硬化性心脏病  经皮冠状动脉介入术  危险因素

英文关键词: elderly  metabolic-associated fatty liver disease  coronary artery disease  percutaneous coronary interven-tion  risk factors

中文摘要:

      目的 分析老年代谢相关脂肪性肝病(MAFLD)合并冠心病(CAD)患者的临床特征.方法 纳入2022年12月—2024年7月在华东医院住院的已完善冠状动脉造影术(CAG)和肝脏超声的1 059例患者,比较MAFLD组和非MAFLD组的组间差异,分析MAFLD及其纤维化程度与CAD的相关性.计量资料采用t检验或秩和检验,计数资料采用x2检验.结果 MAFLD组和非MAFLD组CAD患病率及其严重程度存在统计学差异;高密度脂蛋白、男性、吸烟、血小板、糖化血红蛋白、谷草转氨酶、纤维蛋白原是CAD的主要影响因素;MAFLD纤维化程度评分与CAD呈显著正相关性,经协变量调整后,这一结论仍成立(均P＜0.05).结论 在老年人中,MAFLD在CAD的患病率及严重程度较高,且随着肝纤维化程度加重,CAD患病风险可能增加.

英文摘要:

      Objective To analyze the clinical characteristics of metabolic associated fatty liver disease(MAFLD)com-plicated with coronary artery disease(CAD)in elderly patients.Methods A total of 1 059 patients who underwent coronary angiography(CAG)and hepatic ultrasonography in Huadong Hospital between December 2022 and July 2024 were enrolled.Differences between MAFLD group and non-MAFLD group were compared,and the correlation between MAFLD(including its fibrosis severity)and CAD was analyzed.T-tests or rank sum tests were used to compare measurement data,and Chi-squared test was used to compare categorical data between the two groups.Results There were significant differences in the prevalence and severity of CAD between the MAFLD group and the non-MAFLD group.High-density lipoprotein(HDL),male sex,smoking,platelet count,glycated hemoglobin(HbA1c),aspartate aminotransferase(AST),and fibrinogen were identified as major influencing factors for CAD.The fibrosis degree score of MAFLD was significantly positively correlated with CAD.Af-ter adjusting for covariates,this conclusion still held(all P＜0.05).Conclusion The prevalence and severity of MAFLD in the elderly patients with CAD are relatively high,and the risk of CAD may increase with the progression of liver fibrosis.