CT影像特征联合定量参数在老年甲状腺结节良性及恶性诊断中的价值

Value of CT imaging features combined with quantitative parameters in diagnosis of benign and malignant thyroid nodules in the elderly

中文关键词: 老年  CT影像特征  定量参数  甲状腺结节  良性  恶性  诊断价值

英文关键词: elderly  CT imaging feature  quantitative parameter  thyroid nodule  benign  malignant  diagnostic value

中文摘要:

      目的 探究CT影像特征联合定量参数在老年甲状腺结节良性及恶性诊断中的价值.方法 选取在2022年10月—2024年10月复旦大学附属华东医院收治的经病理检查确诊的甲状腺结节患者80例,其中良性结节60例(良性组),恶性结节20例(恶性组).均经多排螺旋CT检查.记录甲状腺结节的细微结构,结节的部位、直径、形态、边界、钙化及囊变等特征.同时得出CT定量相关参数值.ROC分析CT影像特征联合定量参数在老年甲状腺结节良性及恶性诊断中的价值.结果 与良性组比较,恶性组的形态更加不规则、边界模糊、点颗粒状钙化、存在囊变(P＜0.05).与良性组比较,恶性组平扫期CT值、动脉期CT值、静脉期CT值参数升高(P＜0.05).Logistic回归分析前,进行VIF共线性筛查,最终纳入平扫期CT值、动脉期CT值作为定量参数变量.Logistic回归分析,边界、钙化、囊变、平扫期CT值、动脉期CT值为影响恶性甲状腺结节发生的危险因素(P＜0.05).ROC表明,CT影像特征联合定量参数显著优于单一指标(P＜0.05).结论 CT影像特征联合定量参数在老年甲状腺结节良恶性鉴别中具有较高的应用价值,为临床诊断提供了新的参考依据.

英文摘要:

      Objective To explore the value of CT imaging features combined with quantitative parameters in the diag-nosis of benign and malignant thyroid nodules in the elderly.Methods 80 patients with thyroid nodules diagnosed by patho-logical examination and admitted to Huadong Hospital Affiliated to Fudan University from October 2022 to October 2024 were selected.Among them,there were 60 cases of benign nodules(benign group)and 20 ones of malignant nodules(malignant group).All of them underwent multi-slice spiral CT examination.The fine structure of thyroid nodules,including their loca-tion,diameter,shape,boundary,calcification and cystic changes and other characteristics were recorded.Meanwhile,the rele-vant parameter values of CT quantification were obtained.ROC was used to analyze the value of CT image features combined with quantitative parameters in the diagnosis of benign and malignant thyroid nodules in the elderly.Results Compared with the benign group,the malignant group exhibited more irregular shapes,blurred boundaries,punctate calcifications,and cystic changes(P＜0.05).Compared with the benign group,the CT values during the plain scan,arterial phase,and venous phase were higher in the malignant group(P＜0.05).Before conducting Logistic regression analysis,VIF collinearity screening was performed,and the CT values during the plain scan and arterial phase were ultimately included as quantitative parameter varia-bles.Logistic regression analysis showed that boundary,calcification,cystic change,CT value during plain scan period and CT value during arterial period were the risk factors for the occurrence of malignant thyroid nodules(P＜0.05).ROC analysis in-dicated that the combination of CT image features and quantitative parameters was significantly superior to a single indicator(P＜0.05).(P＜0.05).Conclusion The combination of CT imaging characteristics and quantitative parameters has high application value in the differentiation between benign and malignant thyroid nodules in the elderly.It provides a new reference for clinical diagnosis.