血清前列腺特异抗原与睾酮对老年前列腺癌内分泌治疗疗效的预测价值研究

Study on predictive value of serum levels of prostate-specific antigen and testosterone in efficacy of endocrine therapy in elderly patients with prostate cancer

中文关键词: 老年  前列腺癌  内分泌治疗  睾酮  前列腺特异抗原  预测价值

英文关键词: elderly  prostate cancer  endocrine therapy  testosterone  prostate-specific antigen  predictive value

中文摘要:

      目的 观察老年前列腺癌患者血清前列腺特异抗原(PSA)、睾酮水平在内分泌治疗后的变化情况,并分析二者对内分泌治疗疗效的预测价值.方法 纳入2022年1月—2024年1月三六三医院收治的前列腺癌老年患者155例,所有患者均接受内分泌治疗并评估治疗疗效,同时测定血清PSA、睾酮水平,分析二者水平变化与内分泌治疗疗效的关联性.结果 相对于内分泌治疗前,治疗后PSA、睾酮水平降低,且完全缓解(CR)、部分缓解(PR)、稳定(SD)组PSA、睾酮水平低于进展(PD)组,CR组PSA、睾酮水平低于PR、SD组(P＜0.05).单因素分析发现TNM分期、淋巴结转移、Gleasin评分及PSA、睾酮水平与内分泌治疗疗效有关(P＜0.05).Logistic回归分析发现,TNM分期(Ⅲ期)、无淋巴结转移、Gleasin评分(＜8分)是评估内分泌治疗疗效的正向因素,PSA、睾酮水平是影响内分泌治疗疗效的负向因素.受试者工作特征曲线(ROC)显示PSA+睾酮评估内分泌治疗疗效的AUC为0.840,明显高于PSA单项指标(P＜0.05).结论 老年前列腺癌患者PSA、睾酮水平与内分泌治疗疗效存在一定的关联,可用于临床疗效的评估.

英文摘要:

      Objective To observe changes in the serum levels of prostate-specific antigen(PSA)and testosterone in elderly prostate cancer patients after endocrine therapy,and analyze their predictive value in the efficacy of endocrine therapy.Methods 155 elderly prostate cancer patients admitted to 363 Hospital from January 2022 to January 2024 were enrolled.All patients received endocrine therapy and the efficacy of treatment was assessed.The serum levels of PSA and testosterone were measured,and the correlation between the changes in these levels and efficacy of endocrine therapy was analyzed.Results Com-pared with before endocrine therapy,the serum levels of PSA and testosterone decreased after treatment.The levels of PSA and testosterone in the complete response(CR),partial response(PR),and stable(SD)groups were lower than those in the pro-gressive(PD)group;the levels of PSA and testosterone in the CR group were lower than those in the PR and SD groups(P＜0.05).Univariate analysis showed that TNM stage,lymph node metastasis,Gleason score,PSA level,and testosterone level were associated with the efficacy of endocrine therapy(P＜0.05).Logistic regression model analysis found that TNM stage(stage Ⅲ),no lymph node metastasis,and Gleason score(＜8 points)were positive factors for evaluating the efficacy of en-docrine therapy,while PSA and testosterone were negative factors affecting the efficacy of endocrine therapy(P＜0.05).Re-ceiver operating characteristic curve(ROC)revealed that the AUC of PSA+testosterone in evaluating the efficacy of endo-crine therapy was 0.840,which was significantly higher than that of PSA alone(P＜0.05).Conclusion The serum levels of PSA and testosterone in elderly patients with prostate cancer are correlated with the efficacy of endocrine therapy,which can be used to evaluate the clinical efficacy.