TyG指数联合尿生化指标检测在老年高血压肾病诊断中的价值

Value of TyG index combined with urine biochemical indexes in diagnosis of hypertensive nephropathy in the elderly

中文关键词: 老年  高血压肾病  三酰甘油-葡萄糖指数  尿生化指标  诊断价值

英文关键词: elderly  hypertensive nephropathy  triglyceride-glucose index  urinary biochemical index  diagnostic value

中文摘要:

      目的 探讨三酰甘油-葡萄糖(TyG)指数联合尿生化指标检测在老年高血压肾病诊断中的价值.方法 回顾性选取2023年1月—2024年12月于保定市第二中心医院诊疗的120例老年高血压患者的临床资料,依据是否导致肾病分为高血压肾病组(n=78)与单纯高血压组(n=42).收集2组患者性别、年龄、体质量指数(BMI)、TyG指数、尿N-乙酰-β-D氨基葡萄糖苷酶(NAG)水平、尿微量白蛋白/尿肌酐比值、24 h尿蛋白水平等.采用受试者工作特征(ROC)曲线评估各指标值在老年高血压肾病中的诊断效能.依据病情严重程度将高血压肾病组分为轻度亚组、中度亚组、重度亚组,比较3亚组TyG指数及各项尿生化指标值差异.结果 高血压肾病组TyG指数、尿NAG水平、尿微量白蛋白/尿肌酐比值、24 h尿蛋白水平均高于单纯高血压组,差异有统计学意义(P＜0.001).ROC曲线分析显示,诊断老年高血压肾病时,TyG指数和尿生化指标联合的效能高于单项指标,差异有统计学意义(P＜0.05).高血压肾病轻度亚组、中度亚组、重度亚组患者的TyG指数、尿NAG水平、尿微量白蛋白/尿肌酐比值、24 h尿蛋白水平呈阶梯式升高,组间差异均具有统计学意义(P＜0.05).结论 TyG指数联合尿生化指标检测在老年高血压肾病诊断中展现出显著优势,各指标水平随高血压肾病病情加重而升高,可能有效用于老年高血压肾病的诊断评估.

英文摘要:

      Objective To explore the value of the triglyceride-glucose(TyG)index combined with urinary biochemical indexes in the diagnosis of hypertensive nephropathy in elderly patients.Methods The clinical data of 120 elderly hypertensive patients treated in Second Central Hospital of Baoding City between January 2023 and December 2024 were retrospectively col-lected.Based on the presence of nephropathy,patients were divided into hypertensive nephropathy group(n=78)and simple hypertension group(n=42).The gender,age,body mass index(BMI),TyG index,urinary N-acetyl-β-D-glucosaminidase(NAG)level,urine microalbumin/urine creatinine ratio,24 h urine protein level,etc.of the two groups were collected.Re-ceiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic efficacy of each indicator for hyperten-sive nephropathy in elderly patients.According to disease severity,patients in the hypertensive nephropathy group were divided into mild,moderate and severe subgroups,and differences in TyG index and urinary biochemical indexes were compared a-mong the three subgroups.Results TyG index,urinary NAG level,urine microalbumin/urine creatinine ratio and 24 h urina-ry protein level in the hypertensive nephropathy group were higher than those in the simple hypertension group(P＜0.001).ROC curve analysis showed that the combination of the TyG index and urinary biochemical indexes had significantly higher di-agnostic efficacy for hypertensive nephropathy in the elderly than any single indicator alone(P＜0.05).The TyG index,urine NAG level,urine microalbumin/urine creatinine ratio and 24 h urine protein level of patients in the mild,moderate and severe subgroups increased in a stepwise manner,and the differences among the three subgroups were statistically significant(P＜0.05).Conclusion The combination of TyG index combined with urinary biochemical indexes demonstrates significant ad-vantages in the diagnosis of hypertensive nephropathy in the elderly.The levels of these indexes increase with the aggravation of hypertensive nephropathy,which can be effectively used for the diagnosis and evaluation of hypertensive nephropathy in the elderly.