红细胞分布宽度/白蛋白值与老年维持性血液透析患者心血管事件的相关性研究

A study on correlation between red blood cell distribution width/albumin ratio and cardiovascular events in elderly mainte-nance hemodialysis patients

中文关键词: 老年  红细胞分布宽度/白蛋白值  血液透析  心血管事件

英文关键词: elderly  red blood cell distribution width to albumin ratio  hemodialysis  cardiovascular events

中文摘要:

      目的 探讨红细胞分布宽度/白蛋白值(RAR)与维持性血液透析(MHD)患者及老年MHD人群心血管事件(CVEs)的相关性.方法 回顾性选取2017年1月1日—2024年5月31日在上海交通大学医学院附属同仁医院接受MHD的患者247例,根据基线RAR三分位法将患者分为3组,分析RAR与MHD患者CVEs的相关性及预测价值,根据年龄分为＜65岁和≥65岁进行亚组分析.结果 共入选247例MHD患者,Kaplan-Meier生存曲线显示3组未发生CVEs生存率存在显著差异,中RAR组和高RAR组CVEs发生率均高于低RAR组.多因素Cox回归模型显示,高水平RAR是MHD和老年MHD患者CVEs的独立危险因素.结论 RAR升高是MHD和老年MHD人群CVEs的独立危险因素.

英文摘要:

      Objective To explore the correlation between red blood cell distribution width/albumin ratio(RAR)and cardiovascular events(CVEs)in maintenance hemodialysis(MHD)patients and elderly MHD population.Methods A retro-spective study was conducted on 247 MHD patients treated in Tongren Hospital,Shanghai Jiaotong University School of Medi-cine from January 1,2017 to May 31,2024.They were divided into three groups according to baseline RAR tertiles.The cor-relation between RAR and CVEs,as well as its predictive value,was analyzed.They were further divided into＜65 years old subgroup and ≥65 years old subgroup according to age,and a comparative analysis was conducted between the two subgroups.Results A total of 247 MHD patients were enrolled.Kaplan-Meier survival curves demonstrated significant differences in CVEs-free survival rates among the three RAR groups.The incidence of CVEs in the medium-RAR group and the high-RAR group were higher than that in the low-RAR group.Multivariate Cox regression model showed that RAR was an independent risk factor for CVEs in MHD patients and elderly MHD population.Conclusion Elevated RAR was an independent risk factor for CVEs in MHD patients and elderly MHD population.