CT灌注与磁共振灌注成像对大脑中动脉狭窄脑梗死老年患者大剂量他汀治疗效果评价的比较研究

A comparative study of CT perfusion and magnetic resonance perfusion imaging in evaluating therapeutic effect of high-dose statins on elderly patients with cerebral infarction due to middle cerebral artery stenosis

中文关键词: 老年  中动脉狭窄脑梗死  CT灌注  磁共振灌注成像  他汀治疗  效果  脑血流量

英文关键词: elderly  cerebral infarction due middle artery stenosis  CT perfusion  magnetic resonance perfusion ima-ging  statin therapy  efficacy  cerebral blood volume

中文摘要:

      目的 考察CT灌注与磁共振灌注成像对大脑中动脉狭窄脑梗死老年患者大剂量他汀治疗效果的评价.方法 选取2021年3月—2024年4月淮北矿工总医院收治的100例大脑中动脉狭窄脑梗死老年患者为研究对象.分别于治疗前及治疗后采用CT灌注与磁共振灌注成像对患者进行检查,记录治疗前后患侧与健侧大脑半球的脑血流量(CBF)、脑血容量图(CBV)、达峰时间(TTP)、平均通过时间(MTT)及延迟时间(DT)灌注参数.结果 CT灌注与磁共振灌注成像对治疗后患者病情评估无统计学差异(P＞0.05);CT灌注与磁共振灌注成像显示大脑中动脉狭窄脑梗死患者存在明显异常灌注;CT灌注成像显示,治疗后患者rCBF、rCBV值升高,rTTP及rMTT降低(P＜0.05);磁共振灌注成像显示,治疗后患者rCBF、rCBV值升高,rTTP及rMTT降低(P＜0.05).结论 CT灌注与磁共振灌注成像在大脑中动脉狭窄脑梗死老年患者大剂量他汀治疗效果评估方面均具有一定价值,临床中应依据具体情况选择适当的检查方式.

英文摘要:

      Objective To investigate the evaluation effects of CT perfusion(CTP)and magnetic resonance perfusion imaging(MR-PWI)on the therapeutic effect of high-dose statins in elderly patients with cerebral infarction due to middle cere-bral artery(MCA)stenosis.Methods 100 elderly patients with cerebral infarction caused by MCA stenosis,treated in Huai-bei Miner General Hospital from March 1,2021 to April 30,2024 were enrolled.All patients received high-dose statin treat-ment.Both CTP and MR-PWI examinations were performed before and after treatment.Perfusion parameters,including cerebral blood flow(CBF),cerebral blood volume(CBV),time to peak(TTP),mean transit time(MTT),and delay time(DT),were recorded in both affected and contralateral(healthy)cerebral hemispheres before and after treatment.Results There was no significant difference between CTP and MR-PWI in their assessment of patient condition after treatment(P＞0.05).Both CTP and MR-PWI demonstrated significant perfusion abnormalities in patients with cerebral infarction due to MCA stenosis.CTP imaging showed that after treatment,relative CBF(rCBF)and relative CBV(rCBV)values in the affected hemisphere significantly increased,while relative TTP(rTTP)and relative MTT(rMTT)significantly decreased(P＜0.05).MR-PWI showed that after treatment,the rCBF and rCBV values in the affected hemisphere significantly increased,while rTTP and rMTT significantly decreased(P＜0.05).Conclusion Both CTP and MR-PWI have certain value in evaluating the therapeu-tic effect of high-dose statins in elderly patients with cerebral infarction due to MCA.In clinical practice,appropriate examina-tion methods should be selected based on specific conditions.