外周血EOS、PCT及PLR水平与老年慢性阻塞性肺疾病患者急性加重的相关性分析

Correlation analysis between peripheral blood EOS,PCT and PLR and acute exacerbation in elderly chronic obstructive pul-monary disease patients

中文关键词: 老年  慢性阻塞性肺疾病  嗜酸性粒细胞  降钙素原  血小板  淋巴细胞

英文关键词: elderly  chronic obstructive pulmonary disease  eosinophil  procalcitonin  platelet  lymphocyte

中文摘要:

      目的 探讨外周血嗜酸性粒细胞(Peripheral blood eosinophils,EOS)、降钙素原(procalcitonin,PCT)及外周血血小板/淋巴细胞比值(platelet/lymphocyte ratio,PLR)水平与老年慢性阻塞性肺疾病(chronic obstructive pulmonary dis-ease,COPD)患者急性加重的相关性.方法 随机选取2021年7月—2023年8月合肥市第二人民医院收治的老年COPD患者116例,包括COPD稳定期(SCOPD,32例)、COPD急性加重期(AECOPD,84例),收集一般资料,检测并对比SCOPD、AECOPD患者EOS、PCT及PLR水平;比较AECOPD患者非计划性再入院与未再入院患者的EOS、PCT、PLR水平;绘制受试者工作特征(ROC)曲线,分析EOS、PCT、PLR预测AECOPD患者非计划性再入院的价值.结果 AECOPD组EOS、PCT及PLR水平均高于SCOPD组,非计划性再入院患者EOS、PCT、PLR水平高于未再入院患者(P＜0.05);多因素Logistic回归分析证实EOS、PCT及PLR为COPD急性加重的危险因素(P＜0.05);ROC曲线分析显示EOS预测AECOPD患者非计划性再入院的AUC值最大,并且敏感度为78.05％,特异度为81.40％.结论 AECOPD患者EOS、PCT及PLR对患者非计划性再入院具有一定预测价值.

英文摘要:

      Objective To explore the correlation between peripheral blood eosinophils(EOS),procalcitonin(PCT)and platelet/lymphocyte ratio(PLR)and acute exacerbation in elderly patients with chronic obstructive pulmonary disease(COPD).Methods 116 elderly COPD patients admitted to Second People's Hospital of Hefei City from July 2021 to August 2023 were randomly selected,including 32 cases in the stable phase of COPD(SCOPD),84 ones in the acute exacerbation of COPD(AECOPD).Their general information was collected.The levels of EOS,PCT and PLR were detected and compared between the SCOPD group and AECOPD group.The levels of EOS,PCT and PLR were compared between the AECOPD pa-tients with unplanned readmission and those without readmission.The receiver operating characteristic(ROC)curve was used to analyze the value of EOS,PCT,and PLR in predicting unplanned readmission in patients with AECOPD.Results The lev-els of EOS,PCT and PLR in the AECOPD group were all higher than those in the SCOPD group.The levels of EOS,PCT and PLR in patients with unplanned readmission were higher than those in patients without readmission(P＜0.05).Multivariate Logistic regression analysis confirmed that EOS,PCT and PLR were risk factors for acute exacerbation of COPD(P＜0.05).ROC curve analysis showed that EOS had the largest AUC value in predicting unplanned readmission in patients with AECOPD,with a sensitivity of 78.05％and a specificity of 81.40％.Conclusion EOS,PCT and PLR in AECOPD patients have certain predictive value for unplanned readmission.