上海市某社区老年人代谢相关脂肪性肝病患病情况及其影响因素研究

Prevalence of metabolic associated fatty liver disease among the elderly in a community in Shanghai and its influencing factors

中文关键词: 老年  代谢相关脂肪性肝病  非酒精性脂肪性肝病  脂肪肝  患病情况  影响因素  预防措施

英文关键词: elderly  metabolic associated fatty liver disease  nonalcoholic steatohepatitis  fatty liver  prevalence  risk factor  preventive measure

中文摘要:

      目的 研究老年人群代谢相关脂肪性肝病(MAFLD)的患病现况及其影响因素,为MAFLD的防控提供数据参考.方法 回顾性选取2024年9月—10月于上海市浦东新区塘桥社区卫生服务中心体检的1 145名塘桥街道辖区老年居民的临床资料,分析该社区老年居民MAFLD的患病及一般情况,采用多因素Logistic回归分析患病影响因素.结果 1 145名老年居民中,诊断为MAFLD者有439例(占38.3％);其中男性MAFLD患病率为52.7％,高于女性(27.6％),差异有统计学意义(x2=74.222,P＜0.001);吸烟者、饮酒者的患病率高于不吸烟者、不饮酒者差异有统计学意义(P＜0.05).多因素 Logistic 回归分析显示,性别[OR:0.266(0.186,0.38),P＜0.001]、ALT[OR:1.035(1.012,1.059),P=0.003]、UA[OR:1.004(1.002,1.006),P＜0.001]、TyG 指数[OR:6.783(4.821,9.544),P＜0.001]、合并患高血压[OR:2.598(1.940,3.479),P＜0.001]均是MAFLD的影响因素.结论 老年男性患者MAFLD患病率较高,高血压疾病可能是MAFLD的危险因素,ALT、UA和TyG指数的升高也提示患MAFLD可能性增加.

英文摘要:

      Objective To study the current prevalence and influencing factors of metabolic associated fatty liver disease(MAFLD)in an elderly population,and provide data reference for the prevention and control of MAFLD.Methods The clin-ical data of 1 145 elderly residents from Tangqiao Community who underwent physical examinations in Health Service Center of Tangqiao Community in Pudong New District,Shanghai from September to October 2024 were retrospectively collected.The prevalence of MAFLD and general condition among these residents were analyzed,and multivariate logistic regression was used to analyze the influencing factors of the disease.Results Among the 1 145 residents,439 ones were diagnosed with MAFLD,with a prevalence rate of 38.3％.The prevalence of MAFLD in men was 52.7％,which was significantly higher than that in women(27.6％),and the difference was statistically significant(x2=74.222,P＜0.001).The prevalence rates in smokers and drinkers were higher than those in non-smokers and non-drinkers,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that gender[OR:0.266(0.186,0.38),P＜0.001],alanine amin-otransferase(ALT)[OR:1.035(1.012,1.059),P=0.003],uric acid(UA)[OR:1.004(1.002,1.006),P＜0.001],tri-glyceride-glucose(TyG)[OR:6.783(4.821,9.544),P＜0.001],and combined hypertension[OR:2.598(1.940,3.479),P＜0.001]were all influencing factors of MAFLD.Conclusion The prevalence of MAFLD is relatively high in eld-erly male population.Hypertension may be a risk factor for MAFLD.The elevation of LT,UA and TyG also indicates an in-creased possibility of developing MAFLD.