上海社区老年人群空腹血糖与衰弱的关联研究

A study on association between fasting blood glucose and frailty in community-dwelling elderly people in Shanghai

中文关键词: 老年人  衰弱  空腹血糖  糖尿病  中国衰弱筛查量表  躯体衰弱  抑郁症状  主观认知下降

英文关键词: elderly people  frailty  fasting blood glucose  diabetes mellitus  The Chinese Frailty Screening-10 Scale  physical frailty  depressive symptom  subjective cognitive decline

中文摘要:

      目的 探讨上海社区老年人空腹血糖(FBG)与衰弱及其各维度之间的关联.方法 回顾性选取2020年6月—2020年12月上海市松江区1 501名年龄≥60岁的老年人为研究对象;使用中国衰弱筛查量表评估他们的衰弱状态,根据衰弱状态分期分为稳健期组(n=584,38.9％)、衰弱前期组(n=806,53.7％)、衰弱期组(n=111,7.4％);检测各组FBG水平,根据FBG检测结果分为糖尿病组(n=203)和非糖尿病组(n=1 298).FBG水平以连续变量和四分位数形式纳入分析.采用二元Logistic回归方法分析FBG水平与衰弱状态的关联.采用多元Logistic回归方法分析FBG水平与衰弱各维度的关联.结果 非糖尿病组中,与FBG最低四分位数组(Q1)比较,Q3组有更高的衰弱概率(Q3 vs.Q1:OR=2.29,95％CI=1.19～4.43,P=0.014).FBG和衰弱各维度分析结果显示,非糖尿病组中,较高的FBG水平与更高比例的躯体衰弱、抑郁症状和主观认知下降相关.糖尿病组中未见FBG与衰弱及其各维度之间的关联.结论 非糖尿病老年人需要控制血糖以降低可能的衰弱风险,尤其是在躯体衰弱,抑郁症状及主观认知下降方面.

英文摘要:

      Objective To explore the association between fasting blood glucose(FBG)and frailty,as well as its vari-ous dimensions in community-dwelling elderly people in Shanghai.Methods From June to December,2020,a total of 1 501 elderly people aged ≥60 years from Songjiang District,Shanghai,were included retrospectively as research subjects.The Chi-nese Frailty Screening-10 Scale(CFS-10)was used to assess their frailty status.According to the stage of frailty status,they were divided into stable stage group(n=584,38.9％),pre-frailty stage group(n=806,53.7％),and frailty stage group(n=111,7.4％).Their FBG levels were detected and they were divided into diabetes group(n=203)and non-diabetes group(n=1 298)based on the FBG detection results.The FBG levels were included in the analysis in the form of continuous variables and quartiles.The binary Logistic regression method was used to analyze the association between FBG levels and frailty status.Multivariate logistic regression was used to analyze the association between FBG and each dimension of frailty.Results In the non-diabetic group,compared with the lowest quartile group(Q1)of FBG,the Q3 group had a higher probability of frailty(Q3 vs.Q1:OR=2.29,95％CI=1.19-4.43,P=0.014).The analysis results of FBG and each dimension of frailty showed that in the non-diabetic group,a higher level of FBG was associated with a higher proportion of physical frailty,depres-sive symptoms and subjective cognitive decline.No significant association between FBG and frailty and its various dimensions was observed in the diabetes group.Conclusion The elderly without diabetes need to control blood sugar to reduce the risk of potential frailty,especially in terms of physical frailty,depressive symptoms and subjective cognitive decline.